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Surface modification of magnetite nanoparticle with azobenzene-containing water dispersible polymer

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Abstract

We here report the synthesis of magnetite nanoparticle (MNP) grafted with poly (ethylene glycol) methyl ether methacrylate (PEGMA)-azobenzene acrylate (ABA) statistical copolymer via atom transfer radical polymerization (ATRP) for drug entrapment and photocontrolled release. MNP was synthesized via thermal decomposition of iron (III) acetylacetonate in benzyl alcohol and surface functionalized to obtain ATRP initiating sites. Molar compositions of the copolymer on MNP surface were systematically varied (100:0, 90:10, 70:30, and 50:50 of PEGMA:ABA, respectively) to obtain water dispersible particles with various amounts of azobenzene. The presence of polymeric shell on MNP core was evidenced by transmission electron microscopy (TEM). Drug loading and entrapment efficiencies as well as drug release behavior of the copolymer–MNP complexes were investigated. It was found that when percent of ABA in the copolymers was increased, entrapment and loading efficiencies of prednisolone model drug were enhanced. Releasing rate and percent of the released prednisolone of the complex exposed in UV light were slightly enhanced as compared to the system without UV irradiation. This copolymer–MNP complex with photocontrollable drug release and magnetic field-directed properties is warranted for further studies for potential uses as a novel drug delivery vehicle.

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Acknowledgments

The authors thank the Thailand Research Fund (TRF) (DBG5380001) and Naresuan University for financial funding. The National Research Council of Thailand (NRCT) is also acknowledged. The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education is gratefully acknowledged for financial supports.

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Authors and Affiliations

  1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Naresuan University, Phitsanulok, 65000, Thailand

    Pawinee Theamdee, Rakchart Traiphol, Boonjira Rutnakornpituk, Uthai Wichai & Metha Rutnakornpituk

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  1. Pawinee Theamdee
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  2. Rakchart Traiphol
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  3. Boonjira Rutnakornpituk
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  4. Uthai Wichai
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  5. Metha Rutnakornpituk
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Correspondence to Metha Rutnakornpituk.

Electronic supplementary material

Below is the link to the electronic supplementary material. Supporting Information Available: TGA thermograms of PEGMA-coated MNP and 90:10 PEGMA-ABA-coated MNP. A first-order plot of 100:0 PEGMA-ABA polymer and conversion plots of 70:30 PEGMA-ABA copolymer and 90:10 PEGMA-ABA copolymer.

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Theamdee, P., Traiphol, R., Rutnakornpituk, B. et al. Surface modification of magnetite nanoparticle with azobenzene-containing water dispersible polymer. J Nanopart Res 13, 4463–4477 (2011). https://doi.org/10.1007/s11051-011-0399-7

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  • DOI: https://doi.org/10.1007/s11051-011-0399-7

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