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Erschienen in: Journal of Nanoparticle Research 4/2016

01.04.2016 | Research Paper

Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity

verfasst von: Ondřej Kaman, Tereza Dědourková, Jakub Koktan, Jarmila Kuličková, Miroslav Maryško, Pavel Veverka, Radim Havelek, Karel Královec, Karolína Turnovcová, Pavla Jendelová, Adam Schröfel, Ladislav Svoboda

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2016

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Abstract

Magnetic oxide nanoparticles provide a fascinating tool for biological research and medicine, serving as contrast agents, magnetic carriers, and core materials of theranostic systems. Although the applications rely mostly on iron oxides, more complex oxides such as perovskite manganites may provide a much better magnetic performance. To assess the risk of their potential use, in vitro toxicity of manganite nanoparticles was thoroughly analysed and compared with another prospective system of Mn–Zn ferrite nanoparticles. Magnetic nanoparticles of La0.63Sr0.37MnO3 manganite were prepared by two distinct methods, namely the molten salt synthesis and the traditional sol–gel route, whereas nanoparticles of Mn0.61Zn0.42Fe1.97O4 ferrite, selected as a comparative material, were synthesized by a new procedure under hydrothermal conditions. Magnetic cores were coated with silica and, moreover, several samples of manganite nanoparticles with different thicknesses of silica shell were prepared. The size-fractionated and purified products were analysed using transmission electron microscopy, dynamic light scattering, measurement of the zeta-potential dependence on pH, IR spectroscopy, and SQUID magnetometry. The silica-coated products with accurately determined concentration by atomic absorption spectroscopy were subjected to a robust evaluation of their cytotoxicity by four different methods, including detailed analysis of the concentration dependence of toxicity, analysis of apoptosis, and experiments on three different cell lines. The results, comparing two manganese-containing systems, clearly indicated superior properties of the Mn–Zn ferrite, whose silica-coated nanoparticles show very limited toxic effects and thus constitute a promising material for bioapplications.

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Metadaten
Titel
Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity
verfasst von
Ondřej Kaman
Tereza Dědourková
Jakub Koktan
Jarmila Kuličková
Miroslav Maryško
Pavel Veverka
Radim Havelek
Karel Královec
Karolína Turnovcová
Pavla Jendelová
Adam Schröfel
Ladislav Svoboda
Publikationsdatum
01.04.2016
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 4/2016
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-016-3402-5

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