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Journal of Nanoparticle Research

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01.08.2016 | Research Paper

Mesoporous nanocarriers for the loading and stabilization of 5-aminolevulinic acid

verfasst von: Ivana Miletto, Emanuela Bottinelli, Andrea Siviero, Debora Fabbri, Paola Calza, Gloria Berlier

Erschienen in: Journal of Nanoparticle Research | Ausgabe 8/2016

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Abstract

Mesoporous nanoparticles bearing different surface functionalizations were proposed as host carrier for the loading and stabilization of 5-aminolevulinic acid: unmodified mesoporous silica nanoparticles exposing native silanols and aminopropyltriethoxysilane-grafted mesoporous silica nanoparticles exposing amino groups. The stability of 5-aminolevulinic acid at different steps of drug loading was monitored via electronic and vibrational spectroscopies. Unmodified mesoporous nanoparticles were found to be a host system ensuring the stability of 5-aminolevulinic acid and its availability as protoporphyrin IX precursor, whilst silica surface exposing amino groups was found to strongly favour the dimerization of 5-aminolevulinic acid, leading to the formation of the derived compound pyrazine-2,5-dipropionic acid which is considered to be the major ALA degradation product in aerated solutions, which is no longer active as precursor of protoporphyrin IX. This phenomenon is interpreted in terms of the basic character of amino-modified silica.

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Titel: Mesoporous nanocarriers for the loading and stabilization of 5-aminolevulinic acid
verfasst von: Ivana Miletto
Emanuela Bottinelli
Andrea Siviero
Debora Fabbri
Paola Calza
Gloria Berlier
Publikationsdatum: 01.08.2016
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 8/2016
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-016-3535-6

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