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Surface Modification of Hydrophobic PMMA Intraocular Lens by the Immobilization of Hydroxyethyl Methacrylate for Improving Application in Ophthalmology

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Abstract

To improve application of hydrophobic polymethyl methacrylate intraocular lens (PMMA IOL) in a convenient and continuous way, 2-hydroxyethyl methacrylate (HEMA) was immobilized by dielectric barrier discharge plasma at relatively high pressure. The hydrophilicity and topography of the modified IOL surface were comprehensively evaluated by contact angle and atomic force microscopy, while the surface biocompatibility of the modified IOL was investigated by platelets adhesion and cells proliferation experiments. The results revealed that the hydrophilicity of the HEMA-g-PMMA IOL samples were significantly and permanently improved. Less platelets attachment was observed on the modified IOL, especially in the HEMA2-g-PMMA IOL group (with 1.65 × 10−1 mol/L HEMA concentration), which also suppressed the proliferation of cells.

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Acknowledgment

This work has been supported by the funding support of the Fundamental Research Funds for the Central Universities (GK201004001, GK200901023) and the Program for Changjiang Scholars and Innovative Research Team in University (IRT1070). The authors gratefully acknowledge Mr. Chen Dichun from Xi’an University of Technology for his helps in XPS and AFM characterization.

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Authors and Affiliations

  1. Key Laboratory of Applied Surface and Colloid Chemistry (Shaanxi Normal University), Ministry of Education, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi’an, 710062, China

    Yanlin Wei, Yashao Chen, Qiang Gao & Yu Sun

  2. Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China

    Peng Liu

  3. Able Eye Device Co. Ltd, Zhengzhou, 450008, China

    Changzheng Huang

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  1. Yanlin Wei
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  2. Yashao Chen
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  3. Peng Liu
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  4. Qiang Gao
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  5. Yu Sun
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Correspondence to Yashao Chen.

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Wei, Y., Chen, Y., Liu, P. et al. Surface Modification of Hydrophobic PMMA Intraocular Lens by the Immobilization of Hydroxyethyl Methacrylate for Improving Application in Ophthalmology. Plasma Chem Plasma Process 31, 811–825 (2011). https://doi.org/10.1007/s11090-011-9323-2

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  • DOI: https://doi.org/10.1007/s11090-011-9323-2

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