Abstract
It is shown that the drug teraphthal should be considered as a mixture of the octasodium salt of cobalt(II) 2,3,9,10,16,17,23,24-octacarboxyphthalocyanine (OCPC) and its oxidation product (component A) with the octasodium salt of OCPC and products from the extensive destruction of a substance with a similar elemental composition (component B). The composition can be estimated quantitatively using (i) the results of elemental analysis (H, N, Co) and (ii) PMR in combination with measurement of the weight loss on drying.
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References
State Standard of Quality. Manufacturer's Pharmacopoeic Article MPA 42-0047-1680-01 “Teraphthal.”
J. Houben and T. Weyl, Methoden der organische Chemie, Vol. 4, Halogenverbindungen, 4th Ed., G. Thieme Verlag, Stuttgart (1960).
L. Pauling, The Nature of the Chemical Bond and the Structure of Molecules and Crystals, Cornell Univ. Press, Ithaca (1939).
State Pharmacopoeia, XI Ed., Nos. 1 and 2, Moscow (1998).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 12, pp. 48–53, December, 2007.
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Goizman, M.S., Degterev, E.V., Turchin, K.F. et al. Quality control of teraphthal production. 1. Chemical composition. Pharm Chem J 41, 670–675 (2007). https://doi.org/10.1007/s11094-008-0035-8
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DOI: https://doi.org/10.1007/s11094-008-0035-8