The conditions for spectrophotometric determination of mesalazine in urine using 7-chloro-4,6-dinitrobenzofuroxane as an analytical reagent have been established. The optimum analytical results are achieved at a wavelength of 500 nm for a solution with pH 6 – 8. The detection limit for mesalazine is 0.31 μg/mL. The possibility of using the proposed method for assessing mesalazine acetylation in metabolic processes by individual human phenotypes has been shown.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 12, pp. 48 – 51, December, 2011.
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Garmonov, S.Y., Nguyen, Z.C., Mingazetdinov, I.F. et al. Spectrophotometric determination of mesalazine in urine for assessing the acetylation phenotype in vivo in humans. Pharm Chem J 45, 757–760 (2012). https://doi.org/10.1007/s11094-012-0719-y
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DOI: https://doi.org/10.1007/s11094-012-0719-y