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Functionalized Micellar Systems for Cancer Targeted Drug Delivery

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Abstract

Abstract

Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10–100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood circulation times. Recent data from clinical trials with three micelle formulations have highlighted these and other pharmacokinetic advantages with reduced systemic toxicity and patient morbidity compared to conventional drug formulation. While the initial anti-tumor efficacy of these systems seems promising, a strong research impetus has been placed on micelle functionalization in order to achieve tumor targeting and site-specific drug release, with the hope of reaching a more pronounced tumor response. Hence, the purpose of this review is to draw attention to the new developments of multi-functional polymer micelles for cancer therapy with special focus on tumor targeting and controlled drug release strategies.

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Acknowledgement

We thank the National Institutes of Health (R01-CA-90696 and R21-EB-005394) for their financial support. NN acknowledges the Royal Thai Government for a predoctoral fellowship support. EB acknowledges the predoctoral support from the NCI Minority Supplement Program. This is manuscript CSCNP008 from the “Cell Stress and Cancer Nanomedicine” program in the Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center at Dallas.

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  1. Norased Nasongkla

    Present address: Department of Biopharmaceutical Sciences and Pharmaceutical Chemistry, School of Pharmacy, University of California, San Fransisco, 513 Parnassus Avenue, Health Science East 1145 B, San Francisco, California, 94143, USA

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  1. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas, 75390, USA

    Damon Sutton, Norased Nasongkla, Elvin Blanco & Jinming Gao

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  1. Damon Sutton
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Correspondence to Jinming Gao.

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Sutton, D., Nasongkla, N., Blanco, E. et al. Functionalized Micellar Systems for Cancer Targeted Drug Delivery. Pharm Res 24, 1029–1046 (2007). https://doi.org/10.1007/s11095-006-9223-y

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