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Magnetic Deposition of Aerosols Composed of Aggregated Superparamagnetic Nanoparticles

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Abstract

Purpose

The deposition of magnetic particles was examined for the possibility of further enhancing the selectivity of inhalation drug administration for the treatment of lung cancer.

Methods

Superparamagnetic magnetite nanoparticles were prepared and ultrasonically atomized, dried, and passed through glass tubes in the presence and absence of a wedge-shaped permanent magnet. The change in the outlet aerosol size distribution due to magnetic deposition under various well-defined aerodynamic conditions and a measured magnetic field was determined by an aerodynamic particle sizer. In addition, computational fluid dynamics (CFD) simulations of magnetic aerosol transport and deposition were conducted.

Results

The deposition fraction increased nearly linearly with particle diameter and was greater with lower air flow rates. The effect of tube diameter was complicated but well described by CFD simulations, as was the effect of particle size and air flow rate.

Conclusions

The descriptive power of CFD simulations was demonstrated in the in vitro deposition of magnetic aerosol particles. This suggests that CFD simulations can potentially be used in future studies to design systems for selective drug delivery in vivo as a function of magnetic properties, aerosol characteristics, and respiratory physiology.

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Abbreviations

APS:

Aerodynamic particle sizer

CFD:

Computational fluid dynamics

exp:

Experimental results

id:

Internal diameter

LPM:

Liters per minute

UFD:

User-defined function

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ACKNOWLEDGEMENTS

Yuanyuan Xie was partially supported by the EG Rippie Fellowship. The induced moment was measured by Yun Hao Xu under the direction of Professor Jian Ping Wang. Powerscope Inc. generously arranged for our use of the aerodynamic particle sizer on loan from TSI.

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Authors and Affiliations

  1. Department of Pharmaceutics, University Of Minnesota, Minneapolis, Minnesota, USA

    Yuanyuan Xie, Pengyun Zeng & Timothy Scott Wiedmann

  2. Department of Radiology, University Of Minnesota, Minneapolis, Minnesota, USA

    Bruce E. Hammer

  3. Department of Mechanical Engineering and Department of Pharmaceutics, Virginia Commonwealth University, 401 West Main Street, P.O. Box 843015, Richmond, Virginia, 23284-3015, USA

    P. Worth Longest

  4. Department of Pharmaceutics and Department of Biomedical Engineering, University Of Minnesota, Minneapolis, Minnesota, USA

    Ronald A. Siegel

Authors
  1. Yuanyuan Xie
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  2. Pengyun Zeng
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  3. Ronald A. Siegel
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  4. Timothy Scott Wiedmann
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  5. Bruce E. Hammer
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  6. P. Worth Longest
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Corresponding author

Correspondence to P. Worth Longest.

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Xie, Y., Zeng, P., Siegel, R.A. et al. Magnetic Deposition of Aerosols Composed of Aggregated Superparamagnetic Nanoparticles. Pharm Res 27, 855–865 (2010). https://doi.org/10.1007/s11095-010-0078-x

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  • DOI: https://doi.org/10.1007/s11095-010-0078-x

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