Abstract
Purpose
To analyse the psychometric properties of the EQ-5D in German stroke survivors undergoing neurological rehabilitation.
Methods
The EQ-5D, the Hospital Anxiety and Depression Scale (HADS) and the Stroke Impact Scale (SIS) were completed before (210 subjects) and after (183 subjects) a patient education programme in seven rehabilitation clinics in Bavaria, Germany. A postal follow-up was conducted after 6 months. Acceptance, validity, reliability and responsiveness of the EQ-5D were tested. The SIS subscales were used as external anchors to classify the patients into change groups between the measurements.
Results
The proportion of missing answers ranged from 4.7 to 8.6%. Between 16 and 19% reported no problems in any EQ-5D dimension. At baseline, correlations between EQ-5D index and the SIS subscales ranged from 0.15 (communication) to 0.60 (mobility). Correlations with the EQ VAS were slightly smaller. All scores were reliable in test–retest with intraclass correlations ranging from 0.67 to 0.81. EQ-5D index and EQ VAS were consistently responsive only to improvements in health, showing small- to medium effect sizes (0.27–0.42).
Conclusions
The EQ-5D has shown reasonable validity, reliability and, more limited, responsiveness in stroke patients with mild to moderate limitations of functional status, allowing it to be used in clinical trials in rehabilitation.
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References
Golomb, B. A., Vickrey, B. G., & Hays, R. D. (2001). A review of health-related quality-of-life measures in stroke. Pharmacoeconomics, 19(2), 155–185.
Salter, K. L., Moses, M. B., Foley, N. C., & Teasell, R. W. (2008). Health-related quality of life after stroke: What are we measuring? International Journal of Rehabilitation Research, 31(2), 111–117.
The EuroQol Group. (1990). EuroQol—a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.
Schweikert, B., Hahmann, H., & Leidl, R. (2006). Validation of the EuroQol questionnaire in cardiac rehabilitation. Heart, 92(1), 62–67.
Petrou, S., & Hockley, C. (2005). An investigation into the empirical validity of the EQ-5D and SF-6D based on hypothetical preferences in a general population. Health Economics, 14(11), 1169–1189.
Dorman, P., Slattery, J., Farrell, B., Dennis, M., & Sandercock, P. (1998). Qualitative comparison of the reliability of health status assessments with the EuroQol and SF-36 questionnaires after stroke. United Kingdom Collaborators in the International Stroke Trial. Stroke, 29(1), 63–68.
Dorman, P. J., Dennis, M., & Sandercock, P. (1999). How do scores on the EuroQol relate to scores on the SF-36 after stroke? Stroke, 30(10), 2146–2151.
Dorman, P. J., Waddell, F., Slattery, J., Dennis, M., & Sandercock, P. (1997). Is the EuroQol a valid measure of health-related quality of life after stroke? Stroke, 28(10), 1876–1882.
van Exel, N. J., Scholte op Reimer, W. J., & Koopmanschap, M. A. (2004). Assessment of post-stroke quality of life in cost-effectiveness studies: The usefulness of the Barthel Index and the EuroQoL-5D. Quality of Life Research, 13(2), 427–433.
Pickard, A. S., Johnson, J. A., & Feeny, D. H. (2005). Responsiveness of generic health-related quality of life measures in stroke. Quality of Life Research, 14(1), 207–219.
Neubert, S., Sabariego, C., Stier-Jarmer, M., & Cieza, A. (2011). Development of an ICF-based patient education program. Patient Education and Counseling, 84(2), e13–e17.
Hensler, S., Hoidn, S., & Jork, K. (2006). DEGAM practice guideline for stroke. Zeitschrift für Allgemeinmedizin, 82, 404–408.
Rollnik, J. D., & Janosch, U. (2010). Current trends in the length of stay in neurological early rehabilitation. Deutsches Ärzteblatt international, 107(16), 286–292.
Schupp, W. (1995). Concept for a functional status and handicap-adjustment treatment and rehabilitation service chain in neurologic and neurosurgical management in Germany (“phase model”). Der Nervenarzt, 66(12), 907–914.
Stier-Jarmer, M., Koenig, E., & Stucki, G. (2002). Structures of Early Neurological Rehabilitation (Phase B) in Germany. Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin, 12, 260–271.
Leidl, R., & Reitmeir, P. (2011). A value set for the EQ-5D based on experienced health states: Development and testing for the german population. Pharmacoeconomics, 29(6), 521–534.
Herrmann, C., Buss, U., & Snaith, R. P. (1995). HADS-D—Hospital Anxiety and Depression Scale—Deutsche Version: Ein Fragebogen zur Erfassung von Angst und Depressivität in der somatischen Medizin. Bern: Huber.
Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361–370.
Aben, I., Verhey, F., Lousberg, R., Lodder, J., & Honig, A. (2002). Validity of the beck depression inventory, hospital anxiety and depression scale, SCL-90, and Hamilton depression rating scale as screening instruments for depression in stroke patients. Psychosomatics, 43(5), 386–393.
Duncan, P. W., Wallace, D., Lai, S. M., Johnson, D., Embretson, S., & Laster, L. J. (1999). The stroke impact scale version 2.0. Evaluation of reliability, validity, and sensitivity to change. Stroke, 30(10), 2131–2140.
Petersen, C., Morfeld, M., & Bullinger, M. (2001). Testing and validation of the German version of the Stroke Impact Scale. Fortschritte der Neurologie-Psychiatrie, 69(6), 284–290.
Geyh, S., Cieza, A., & Stucki, G. (2009). Evaluation of the German translation of the Stroke Impact Scale using Rasch analysis. The Clinical Neuropsychologist, 23(6), 978–995.
Hamilton, B., & Granger, C. V. (1987). A uniform national data system for medical rehabilitation. In M. Fuhrer (Ed.), Rehabilitation outcomes: analysis and measurement (pp. 137–147). Baltimore, MD: Brookes Publishing Co.
van der Putten, J. J., Hobart, J. C., Freeman, J. A., & Thompson, A. J. (1999). Measuring change in disability after inpatient rehabilitation: Comparison of the responsiveness of the Barthel index and the functional independence measure. Journal of Neurology, Neurosurgery and Psychiatry, 66(4), 480–484.
Hall, K. M., Hamilton, B. B., Gordon, W. A., & Zasler, N. D. (1993). Characteristics and comparisons of functional assessment indices: Disability Rating Scale, functional independence measure, and functional assessment measure. The Journal of Head Trauma Rehabilitation, 8(2), 60–74.
Hobart, J. C., Lamping, D. L., Freeman, J. A., Langdon, D. W., McLellan, D. L., Greenwood, R. J., et al. (2001). Evidence-based measurement: Which disability scale for neurologic rehabilitation? Neurology, 57(4), 639–644.
Hsueh, I. P., Lin, J. H., Jeng, J. S., & Hsieh, C. L. (2002). Comparison of the psychometric characteristics of the functional independence measure, 5 item Barthel index, and 10 item Barthel index in patients with stroke. Journal of Neurology, Neurosurgery and Psychiatry, 73(2), 188–190.
Duncan, P. W., Reker, D. M., Horner, R. D., Samsa, G. P., Hoenig, H., LaClair, B. J., et al. (2002). Performance of a mail-administered version of a stroke-specific outcome measure, the Stroke Impact Scale. Clinical Rehabilitation, 16(5), 493–505.
Carod-Artal, F. J., Coral, L. F., Trizotto, D. S., & Moreira, C. M. (2008). The stroke impact scale 3.0: Evaluation of acceptability, reliability, and validity of the Brazilian version. Stroke, 39(9), 2477–2484.
Carod-Artal, J., Egido, J. A., Gonzalez, J. L., & Varela de Seijas, E. (2000). Quality of life among stroke survivors evaluated 1 year after stroke: Experience of a stroke unit. Stroke, 31(12), 2995–3000.
Revicki, D., Hays, R. D., Cella, D., & Sloan, J. (2008). Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes. Journal of Clinical Epidemiology, 61(2), 102–109.
Shrout, P. E., & Fleiss, J. L. (1979). Intraclass correlations: Uses in assessing rater reliability. Psychological Bulletin, 86(2), 420–428.
Konig, H. H., Bernert, S., Angermeyer, M. C., Matschinger, H., Martinez, M., Vilagut, G., et al. (2009). Comparison of population health status in six European countries: Results of a representative survey using the EQ-5D questionnaire. Medical Care, 47(2), 255–261.
Ahlsio, B., Britton, M., Murray, V., & Theorell, T. (1984). Disablement and quality of life after stroke. Stroke, 15(5), 886–890.
Streiner, D. L., & Geoffrey, R. N. (1995). Health Measurement Scales. A practical guide to their development and use (2nd ed.). New York: Oxford University Press.
Landis, J. R., & Koch, G. G. (1977). The measurement of observer agreement for categorical data. Biometrics, 33(1), 159–174.
Cohen, J. (1992). A power primer. Psychological Bulletin, 112(1), 155–159.
Dolan, P., Gudex, C., Kind, P., & Williams, A. (1996). The time trade-off method: results from a general population study. Health Economics, 5(2), 141–154.
Greiner, W., Claes, C., Busschbach, J. J., & von der Schulenburg, J. M. (2005). Validating the EQ-5D with time trade off for the German population. European Journal of Health Economics, 6(2), 124–130.
Acknowledgments
The RCT evaluating the ICF-based patient education was supported by the German Federal Ministry of Education and Research (BMBF). We acknowledge with thanks for time and information provided by the study participants.
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Hunger, M., Sabariego, C., Stollenwerk, B. et al. Validity, reliability and responsiveness of the EQ-5D in German stroke patients undergoing rehabilitation. Qual Life Res 21, 1205–1216 (2012). https://doi.org/10.1007/s11136-011-0024-3
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DOI: https://doi.org/10.1007/s11136-011-0024-3