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Complexes of glutathione with heavy metals as catalysts for oxidation

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Abstract

Research was carried out to determine the activity of complexes of tripeptide–glutathione with heavy metals in the oxidation of cyclohexene with tert-butylhydroperoxide in toluene at 80 °C. All the complexes were prepared by the interaction of metal ions and glutathione at room temperature in aqueous solutions. Only the complexes of Mo were obtained from acidic aqueous solution. The characteristics of these complexes were determined by means of FTIR and Mössbauer spectroscopies and EPR analysis. The products of the epoxidation and hydroxylation reactions were identified using GC analysis. The complexes of molybdenum and vanadium showed higher activity in the epoxidation reaction of cyclohexene compared to the other complexes, namely of Mn, Co, Cu, Cr, Fe, Cd and Th. The possible structures of the complexes are offered. The possible use of glutathione complexes as catalysts in the model reaction of oxidation is newly demonstrated.

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Acknowledgments

The authors would like to thank Prof. DSc Ivan Mitov and Dr Daniela Paneva, Institute of Catalysis, Bulgarian Academy of Sciences, for the many useful discussions of Mössbauer spectra.

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Authors and Affiliations

  1. Department of Biotechnology, Prof. Assen Zlatarov University, 1 Y. Yakimov St., 8010, Burgas, Bulgaria

    Marina Dimitrova & Krassimir Vassilev

  2. Department of Materials Science, Prof. Assen Zlatarov University, 1 Y. Yakimov St., 8010, Burgas, Bulgaria

    Sevdalina Turmanova

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  1. Marina Dimitrova
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  2. Sevdalina Turmanova
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  3. Krassimir Vassilev
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Correspondence to Sevdalina Turmanova.

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Dimitrova, M., Turmanova, S. & Vassilev, K. Complexes of glutathione with heavy metals as catalysts for oxidation. Reac Kinet Mech Cat 99, 69–78 (2010). https://doi.org/10.1007/s11144-009-0118-x

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