Skip to main content
SpringerLink
Log in

Starch cellulose acetate co-acrylate (SCAA) polymer as a drug carrier

  • Published:
Research on Chemical Intermediates Aims and scope Submit manuscript

Abstract

The present study aims to create a controlled-release system through the preparation and characterization of starch cellulose acetate co-acrylate (SCAA) polymer for application as a carrier for cancer drugs. SCA was prepared from maize starch and different ratios of cellulose acetate. The obtained product SCA was reacted with acrylic acid monomer to give cellulose acetate co-acrylate. The best ratio of starch to cellulose acetate was found to be 90:10, giving a stable product with acrylic acid. The cancer drug 8-(2-methoxyphenyl)-3,4-dioxo-6-thioxo-3,4,6,7-tetrahydro-2h-pyrimido[6,1-c]-[1,2,4]triazine-9-carbonitrile was dissolved in dimethylformamide then added gradually at the end of the previous reaction under stirring for 15 min. The prepared polymers with and without the drug were characterized by Fourier-transform infrared spectroscopy. Cuboids discs of the prepared polymer/drug were subjected to drug release in aqueous media at different pH values. The release was measured spectrophotometrically. It was found that the release rate depends on the pH of the aqueous medium as well as on the concentration of the drug loaded onto the polymer carrier. Above pH 12, the polymer containing the drug degraded completely within 1 h after being subjected to alkaline media. Sustained release of drug extended to about 20 days. The amount released depended on the pH of the media in the following order: basic media > acidic media > neutral. According to Higuch’s equation, the diffusion coefficient was found to be 4.2 × 10−8 and 5.5 × 10−8 cm s−1 for the two evaluated concentrations (1.5 and 2 %) of active organic compound (drug).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. H. Yueying, Z. Yan, G. Chunhua, D. Weifeng, L. Meidong, Micellar carrier based on methoxy poly(ethylene glycol)—blockpoly (ε caprolactone) block copolymers bearing ketone groups on the polyester block for doxorubicin deliverys. J. Mater. Sci. 21, 567–574 (2010)

    Google Scholar 

  2. S. Bontha, A.V. Kabanov, T.K. Bronich, Polymer micelles with crosslinked ionic cores for delivery of anticancer drugs. J. Control. Release 114, 163–174 (2006)

    Article  CAS  Google Scholar 

  3. S. Dhawan, K. Dhawan, M. Varma, V.R. Sinha, Applications of poly(ethylene oxide) in drug delivery systems, part II. Pharm. Technol. 29, 82–96 (2005)

    CAS  Google Scholar 

  4. D.B. Shenoy, M.M. Amiji, Poly(ethylene oxide)-modified poly(ε-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer. Int. J. Pharm. 293, 261–270 (2005)

    Article  CAS  Google Scholar 

  5. C.S. Pereira, A.M. Cunha, R.L. Reis, New starch-based thermoplastic hydrogels for use as bone cements or drug-delivery carriers. J. Mater. Sci. 9, 825–833 (1998)

    CAS  Google Scholar 

  6. Y. Xu, V. Miladinov, M.A. Hanna, Synthesis and characterization of starch acetates with high substitution. Cereal Chem. 81, 735–740 (2004)

    Article  CAS  Google Scholar 

  7. H. Lua, L. Zhanga, C. Wanga, R. Chen, Preparation and properties of new micellar drug carriers based on hydrophobically modified amylopectin. Carbohydr. Polym. 83, 1499–1506 (2011)

    Article  Google Scholar 

  8. I. Silva, M. Gurruchaga, I. Goni, Physical blends of starch graft copolymers as matrices for colon targeting drug delivery systems. Carbohydr. Polym. 76, 593–601 (2009)

    Article  CAS  Google Scholar 

  9. A.I. Khalf, D.E. El Nashar, N.A. Maziad, Effect of grafting cellulose acetate and methylmethacrylate as compatibilizer onto NBR/SBR blends. Mater. Des. 31, 2592–2598 (2010)

    Article  CAS  Google Scholar 

  10. O.A. Fathalla, I.F. Zeid, M.E. Haiba, A.M. Soliman, Sh.I. Abd-Elmoez, W.S. El-Serwy, Synthesis, antibacterial and anticancer evaluation of some pyrimidine derivatives. World J. Chem. 4, 127–132 (2009)

    CAS  Google Scholar 

  11. F. Marson, J Oil Color Chem Assoc 47, 323 (1964)

    Google Scholar 

  12. K.G. Das, Controlled Release Technology (Wiley Interscience, New York, 1983)

    Google Scholar 

  13. T. Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension. J. Pharm. Sci. 50, 874–875 (1961)

    Article  CAS  Google Scholar 

  14. T. Higuch, Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52, 1145–1149 (1963)

    Article  Google Scholar 

  15. M.A. Kalam, M. Humayun, N. Parvez, S. Yadav, A. Garg, S. Amin, Y. Sultana, A. Ali, Release kinetics of modified pharmaceutical dosage forms. A review. Cont. J. Pharm. Sci. 1, 30–35 (2007)

    Google Scholar 

  16. F.M. Helaly, D.E. El Nashar, A.I. Khalaf, Controlling the release of active iron and manganese ions from styrene-butadiene rubber-binding matrix containing chloride salts of them. J. Appl. Polym. Sci. 113, 811–817 (2009)

    Article  CAS  Google Scholar 

  17. X. Li, J. You, F. Cui, Y. Du, H. Yuan, F. Hu, Preparation and characterization of stearic acid grafted chitosan oligosaccharide polymeric micelle containing 10-hydroxycamptothecin. J. Pharm. Sci. 3, 80–87 (2008)

    Article  Google Scholar 

  18. X. Gu, Y. Kuang, X. Guo, J. Fang, Z. Ni, Synthesis and drug release properties of poly(ethylene oxide) segmented polysulfone copolymers. J. Control. Release 127, 267–272 (2008)

    Article  CAS  Google Scholar 

  19. X. Wang, S.S. Venkatraman, F.Y.C. Boey, J.S.C. Loo, L.P. Tan, Controlled release of sirolimus from a multilayered PLGA stent matrix. Biomaterials 27, 5588–5595 (2006)

    Article  CAS  Google Scholar 

  20. Y. Chang, J.D. Bender, M.V.B. Phelps, H.R. Allcock, Synthesis and self association behavior of biodegradable amphiphilic poly [bis(ethyl glycinat-N-yl)phosphazene]-poly(ethylene oxide) block copolymers. Biomacromolecules 3, 1364–1369 (2002)

    Article  CAS  Google Scholar 

  21. A. Potineni, D.M. Lynn, R. Langer, M.M. Amiji, Poly(ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. J. Control. Release 86, 223–234 (2003)

    Article  CAS  Google Scholar 

  22. S. Nicoli, P. Colombo, P. Santi, Release and permeation kinetics of caffeine from bioadhesive. AAPS J 7, 218–223 (2005)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Polymers and Pigments Department, National Research Center, Cairo, Egypt

    F. M. Helaly, A. I. Khalaf & D. El Nashar

Authors
  1. F. M. Helaly
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. I. Khalaf
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. El Nashar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. El Nashar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Helaly, F.M., Khalaf, A.I. & El Nashar, D. Starch cellulose acetate co-acrylate (SCAA) polymer as a drug carrier. Res Chem Intermed 39, 3209–3220 (2013). https://doi.org/10.1007/s11164-012-0833-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11164-012-0833-1

Keywords

Search

Navigation