Abstract
A method was developed for chitosan modification using the multicomponent Ugi reaction. The obtained products are highly soluble in water in a wide range of pH 2–11. They were used for the stabilization of liposomal suspensions based on phosphatidylcholin, which retained colloidal stability for three months upon the addition of modified chitosan in a ratio of 1: 5.
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Dedicated to Academician of the Russian Academy of Sciences O. N. Chupakhin on the occasion of his 80th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1619–1623, July, 2014.
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Ponomarev, V.S., Kozhikhova, K.V., Shulepov, I.D. et al. Synthesis of water-soluble chitosan derivatives and their use for the stabilization of liposomal suspensions. Russ Chem Bull 63, 1619–1623 (2014). https://doi.org/10.1007/s11172-014-0644-1
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DOI: https://doi.org/10.1007/s11172-014-0644-1