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The effect of ascorbic acid on the efficiency of cytotoxic therapy with cytostatic drugs in combination with NaNO3 and hydroxamic acids

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Abstract

The present investigation is based on the paradoxical dichotomy of the biological action of nitric oxide (NO). Depending on its concentration in the organism, it can have therapeutic or pathogenic effect. It was shown that during the treatment with cisplatin (cPt) or cyclophospamide (CP), adjunct therapy with ascorbic acid (AA) known to increase the NO content in the organism extended the average lifespan (ALS) by 20—30% as compared to cytostatic monotherapy. Combination of cytostatics with sodium nitrate extended ALS by 20—38% depending on the concentration of the nitrate. The efficiency of cytotoxic therapy in combination with two chemo sensitizers (NaNO3 and hydroxamic acid) also depends on the concentration of injected NaNO3. Addition of AA to these combinations extended ALS by 16%, or inhibited it by 40%. Variation of the dose of injected NaNO3 that is a NO donor in combination with endogenous NO stimulated with AA controls the action of cytostatics and combinations thereof.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. N. N. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    T. N. Bogatyrenko, T. E. Sashenkova, D. V. Mishchenko, V. R. Bogatyrenko & N. P. Konovalova

  2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 111999, Moscow, Russian Federation

    Z. V. Kuropteva & L. M. Bayder

Authors
  1. T. N. Bogatyrenko
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  2. Z. V. Kuropteva
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  3. L. M. Bayder
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  4. T. E. Sashenkova
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  5. D. V. Mishchenko
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  6. V. R. Bogatyrenko
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  7. N. P. Konovalova
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Corresponding author

Correspondence to T. N. Bogatyrenko.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0561—0565, February, 2016.

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Bogatyrenko, T.N., Kuropteva, Z.V., Bayder, L.M. et al. The effect of ascorbic acid on the efficiency of cytotoxic therapy with cytostatic drugs in combination with NaNO3 and hydroxamic acids. Russ Chem Bull 65, 561–565 (2016). https://doi.org/10.1007/s11172-016-1337-8

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  • DOI: https://doi.org/10.1007/s11172-016-1337-8

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