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Mixed-ligand chromium(III)-oxalate-pirydinedicarboxylate complexes: potential biochromium sources: kinetic studies in NaOH solutions and effect on 3T3 fibroblasts proliferation

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Abstract

Base hydrolysis of [Cr(ox)2(pda)]3− (where pda is N,O-bonded 2,4- and 2,5- pyridinedicarboxylic acid dianion) causes successive ligand dissociation and leads to formation of a mixture of oligomeric chromium(III) species, known as chromates(III). The main reaction path proceeds through [Cr(ox)(pda)(OH)2]3− and [Cr(pda)(OH)4]3− complexes. The kinetics of the first oxalate dissociation was studied spectrophotometrically, within the lower energy d–d band region, at 0.4–1.0 M NaOH. The character of spectroscopic changes was consistent with a consecutive reaction model, where the chelate-ring opening and the one-end bonded oxalato liberation are the first and the second reaction stages. The pseudo-first order rate constants (k obs0 and k obs1) were calculated using SPECFIT software for an A → B → C reaction pattern. Additionally, kinetics of base hydrolysis of [Cr(ox)3]3− were studied. The calculated rate constants were independent of [OH−]. Kinetic parameters for the chelate-ring opening and the first oxalate dissociation were determined. Effect of the [Cr(ox)2(pda)]3− and [Cr(2,4-pda)3]3− complexes on 3T3 fibroblasts proliferation was studied. The results manifested low cytotoxicity of these complexes, which makes them promising candidates for dietary supplements.

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Acknowledgments

Hasan Marai wishes to thank Libyan Government for financial support of his Ph.D. studies in Poland.

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Authors and Affiliations

  1. Department of Chemistry, N. Copernicus University, 87-100, Toruń, Poland

    Ewa Kita, Hasan Marai & Lisiak Michał

  2. Department of Tissue Engineering, N. Copernicus University, 850-092, Bydgoszcz, Poland

    Miłosz Jasiński & Tomasz Drewa

Authors
  1. Ewa Kita
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  2. Hasan Marai
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  3. Lisiak Michał
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  4. Miłosz Jasiński
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  5. Tomasz Drewa
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Correspondence to Ewa Kita.

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Kita, E., Marai, H., Michał, L. et al. Mixed-ligand chromium(III)-oxalate-pirydinedicarboxylate complexes: potential biochromium sources: kinetic studies in NaOH solutions and effect on 3T3 fibroblasts proliferation. Transition Met Chem 35, 177–184 (2010). https://doi.org/10.1007/s11243-009-9311-z

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  • DOI: https://doi.org/10.1007/s11243-009-9311-z

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