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Optical Surgical Navigation for Precision in Tumor Resections

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Abstract

Optical imaging methods have significant potential as effective intraoperative tools to visualize tissues, cells, and biochemical events aimed at objective assessment of the tumor margin and guiding the surgeon to adequately resect the tumor while sparing critical tissues. The wide variety of approaches to guide resection, the range of parameters that they detect, and the interdisciplinary nature involving biology, chemistry, engineering, and medicine suggested that there was a need for an organization that could review, discuss, refine, and help prioritize methods to optimize patient care and pharmaceutical and instrument development. To address these issues, the World Molecular Imaging Society created the Optical Surgical Navigation (OSN) interest group to bring together scientists, engineers, and surgeons to develop the field to benefit patients. Here, we provide an overview of approaches currently under clinical investigation for optical surgical navigation and offer our perspective on upcoming strategies.

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Author Contribution

S.H. and N.T. wrote the manuscript. M.F.T., J.P.B., and E.L.R. wrote and revised the manuscript. All authors reviewed and approved the manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, Stanford University, Stanford, CA, USA

    Stefan Harmsen

  2. Department of Otolaryngology—Head and Neck Surgery, Stanford University, Stanford, CA, USA

    Nutte Teraphongphom

  3. Department of Radiology, The Wright Center for Innovation in Biomedical Imaging, The Ohio State University College of Medicine, Columbus, OH, USA

    Michael F. Tweedle

  4. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA

    James P. Basilion

  5. Department of Radiology, Case Western Reserve University, Cleveland, OH, USA

    James P. Basilion

  6. National Foundation for Cancer Research Center for Molecular Imaging, Case Western Reserve University, Cleveland, OH, USA

    James P. Basilion

  7. Department of Otolaryngology—Head and Neck Surgery and Radiology, Stanford University, Stanford, CA, USA

    Eben L. Rosenthal

  8. Ann and John Doerr Medical Director, Stanford Cancer Center, Stanford, CA, USA

    Eben L. Rosenthal

Authors
  1. Stefan Harmsen
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  2. Nutte Teraphongphom
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  3. Michael F. Tweedle
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  4. James P. Basilion
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  5. Eben L. Rosenthal
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Corresponding author

Correspondence to Eben L. Rosenthal.

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Conflict of Interests

S.H., N.T., M.F.T., and E.L.R. declare no conflicts of interests. J.P.B. has an interest in Akrotome Imaging Inc., a company developing probes in this space, and consults for Vergent Biosciences and LightPoint Medical Ltd.

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Harmsen, S., Teraphongphom, N., Tweedle, M.F. et al. Optical Surgical Navigation for Precision in Tumor Resections. Mol Imaging Biol 19, 357–362 (2017). https://doi.org/10.1007/s11307-017-1054-1

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  • DOI: https://doi.org/10.1007/s11307-017-1054-1

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