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Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects

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A Correction to this article was published on 10 November 2023

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Abstract

Magnetic particle imaging (MPI) is a novel quantitative imaging technique using the nonlinear magnetization behavior of magnetic nanoparticles (MNPs) to determine their local concentration. Magnetic fluid hyperthermia (MFH) is a promising non-invasive therapy using the heating effects of MNPs. MPI-MFH is expected to enable real-time MPI guidance, localized MFH, and non-invasive temperature monitoring, which shows great potential for precise treatment of cancer. In this review, we introduce the fundamentals of MPI and MFH and their applications in the treatment of cancer. Also, we discuss the challenges and prospects of MPI-MFH.

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Funding

This work was supported in part by the National Key Research and Development Program of China under Grant: 2017YFA0700401; the National Nature Science Foundation of China under Grants: 62027901, 81827808, 81930053, and 81227901; the Beijing Natural Science Foundation (JQ22023); the CAS Youth Innovation Promotion Association under Grant: Y2022055; the Guangdong Key Research and Development Program of China (2021B0101420005); and the Project of High-Level Talents Team Introduction in Zhuhai City (Zhuhai HLHPTP201703).

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  1. Siao Lei and Jie He contributed equally to this work.

Authors and Affiliations

  1. School of Engineering Medicine & School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China

    Siao Lei, Jie He, Pengli Gao, Yu An & Jie Tian

  2. Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, 100191, People’s Republic of China

    Siao Lei, Jie He, Pengli Gao, Yu An & Jie Tian

  3. CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, 100190, China

    Siao Lei, Jie He, Pengli Gao, Yueqi Wang, Hui Hui, Yu An & Jie Tian

  4. Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Affiliated With Jinan University, Zhuhai, 519000, China

    Jie Tian

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  1. Siao Lei
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Correspondence to Yu An or Jie Tian.

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Lei, S., He, J., Gao, P. et al. Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects. Mol Imaging Biol 25, 1020–1033 (2023). https://doi.org/10.1007/s11307-023-01856-z

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