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Detection of tris-(2, 3-dibromopropyl) isocyanurate as a neuronal toxicant in environmental samples using neuronal toxicity-directed analysis

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Abstract

Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region.

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Authors and Affiliations

  1. State Key Laboratory of Environmental Chemistry and Ecotoxicology; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China

    GuangBo Qu, JianBo Shi, ZhuoNa Li, Ting Ruan, JianJie Fu, Pu Wang, Thanh Wang & GuiBin Jiang

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  1. GuangBo Qu
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  2. JianBo Shi
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  3. ZhuoNa Li
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  4. Ting Ruan
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  5. JianJie Fu
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  6. Pu Wang
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  7. Thanh Wang
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  8. GuiBin Jiang
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Correspondence to GuiBin Jiang.

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Qu, G., Shi, J., Li, Z. et al. Detection of tris-(2, 3-dibromopropyl) isocyanurate as a neuronal toxicant in environmental samples using neuronal toxicity-directed analysis. Sci. China Chem. 54, 1651–1658 (2011). https://doi.org/10.1007/s11426-011-4371-2

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  • DOI: https://doi.org/10.1007/s11426-011-4371-2

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