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Preparation of molecularly imprinted microspheres by photo-grafting on supports modified with iniferter

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Chinese Science Bulletin

Abstract

Molecularly imprinted microspheres (MIMs) of D-mandelic acid were synthesized in this study. Chloromethylated polystyrene beads modified with iniferter were used as supports for photo-grafting of a molecularly imprinted polymer (MIP) layer. The polymers were characterized by FT-IR, elemental analysis and thermo-gravimetric analysis to testify the polymer formation and its thermal stability. Scanning electron micrographs (SEM) show that the MIP particles are mono-dispersed and well-spherical, with the average diameter of 4.38 μm and size distribution coefficient of 1.02. Furthermore, the MIMs were packed in a stainless steel column and evaluated as stationary phases in high performance liquid chromatography (HPLC). The prepared MIP exhibited a considerable capability of chiral separation between template and its enantiomer. Accordingly, this kind of MIP is likely to have wide applications in chemical sensing, chromatographic analysis and solid phase extraction.

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Authors and Affiliations

  1. State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China

    Rong Fei, Feng Xiaogang, Yuan Chunwei & Fu Degang

  2. Bioengineering Department, Beijing University of Aeronautics and Astronautics, Beijing, 100083, China

    Li Ping

Authors
  1. Rong Fei
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  2. Feng Xiaogang
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  3. Li Ping
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  4. Yuan Chunwei
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  5. Fu Degang
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Corresponding author

Correspondence to Fu Degang.

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Rong, F., Feng, X., Li, P. et al. Preparation of molecularly imprinted microspheres by photo-grafting on supports modified with iniferter. CHINESE SCI BULL 51, 2566–2571 (2006). https://doi.org/10.1007/s11434-006-2170-5

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  • DOI: https://doi.org/10.1007/s11434-006-2170-5

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