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Shape-memory and biocompatibility properties of segmented polyurethanes based on poly(L-lactide)

  • Research Article
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Frontiers of Chemistry in China

Abstract

A series of segmented poly(L-lactide)-polyurethanes (PLA-PUs) were synthesized by a two-step method, with oligo-poly(L-lactide) (PLA) as the soft segments and the reaction product of 2,4-toluene diisocyanate (TDI) and ethylene glycol (EG) as the hard segments. The shape-memory properties and biocompatibility of PLA-PUs were examined. The 50% compressed PLA-PUs could recover almost 100% to their original shape within 10°C from the lowest recovery temperature (22°C–37°C). In the recovery process the PLA-PU showed a maximum contracting stress in the range of 1.5–4 MPa. Cell incubation experiments show that PLA-PU has biocompatibility comparable to that of pure PLA. Therefore, this kind of polyurethane can be used for implanted medical devices with shape memory requirements.

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Authors and Affiliations

  1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Ping Peng, Wang Wenshou, Zhang Peibiao, Chen Xuesi & Jing Xiabin

  2. Graduate University of Chinese Academy of Sciences, Beijing, 100039, China

    Ping Peng & Wang Wenshou

Authors
  1. Ping Peng
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  2. Wang Wenshou
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  3. Zhang Peibiao
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  4. Chen Xuesi
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  5. Jing Xiabin
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Corresponding author

Correspondence to Jing Xiabin.

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Translated from Chemical Journal of Chinese Universities, 2007, 28(2): 371–375 [译自: 高等学校化学学报]

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Ping, P., Wang, W., Zhang, P. et al. Shape-memory and biocompatibility properties of segmented polyurethanes based on poly(L-lactide). Front. Chem. China 2, 331–336 (2007). https://doi.org/10.1007/s11458-007-0063-z

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  • DOI: https://doi.org/10.1007/s11458-007-0063-z

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