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A Model of CatSper Channel Mediated Calcium Dynamics in Mammalian Spermatozoa

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Abstract

CatSpers are calcium (Ca2+) channels that are located along the principal piece of mammalian sperm flagella and are directly linked to sperm motility and hyperactivation. It has been observed that Ca2+ entry through CatSper channels triggers a tail to head Ca2+ propagation in mouse sperm, as well as a sustained increase of Ca2+ in the head. Here, we develop a mathematical model to investigate this propagation and sustained increase in the head. A 1-d reaction-diffusion model tracking intracellular Ca2+ with flux terms for the CatSper channels, a leak flux, and plasma membrane Ca2+ clearance mechanism is studied. Results of this simple model exhibit tail to head Ca2+ propagation, but no sustained increase in the head. Therefore, in this model, a simple plasma membrane pump-leak system with diffusion in the cytosol cannot account for these experimentally observed results. It has been proposed that Ca2+ influx from the CatSper channels induce additional Ca2+ release from an internal store. We test this hypothesis by examining the possible role of Ca2+ release from the redundant nuclear envelope (RNE), an inositol 1,4,5-trisphosphate (IP3) gated Ca2+ store in the neck. The simple model is extended to include an equation for IP3 synthesis, degradation, and diffusion, as well as flux terms for Ca2+ in the RNE. When IP3 and the RNE are accounted for, the results of the model exhibit a tail to head Ca2+ propagation as well as a sustained increase of Ca2+ in the head.

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Abbreviations

IP3 :

inositol 1,4,5-trisphosphate

RNE:

redundant nuclear envelope

IP3R:

inositol 1,4,5-trisphosphate receptor

Ca2+ :

Calcium

[Ca2+]:

Calcium concentration

cAMP:

cyclic adenosine monophosphate

PMCA:

plasma membrane Ca2+-ATPase

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  1. Mathematics Department, Tulane University, 6823 St. Charles Ave., New Orleans, LA, 70118, USA

    Sarah D. Olson & Lisa J. Fauci

  2. Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

    Susan S. Suarez

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  1. Sarah D. Olson
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Correspondence to Sarah D. Olson.

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Olson, S.D., Suarez, S.S. & Fauci, L.J. A Model of CatSper Channel Mediated Calcium Dynamics in Mammalian Spermatozoa. Bull. Math. Biol. 72, 1925–1946 (2010). https://doi.org/10.1007/s11538-010-9516-5

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