Skip to main content
Erschienen in: Cognitive Neurodynamics 2/2008

01.06.2008 | Research Article

Cortical network dynamics with time delays reveals functional connectivity in the resting brain

verfasst von: A. Ghosh, Y. Rho, A. R. McIntosh, R. Kötter, V. K. Jirsa

Erschienen in: Cognitive Neurodynamics | Ausgabe 2/2008

Einloggen

Aktivieren Sie unsere intelligente Suche um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

In absence of all goal-directed behavior, a characteristic network of cortical regions involving prefrontal and cingulate cortices consistently shows temporally coherent fluctuations. The origin of these fluctuations is unknown, but has been hypothesized to be of stochastic nature. In the present paper we test the hypothesis that time delays in the network dynamics play a crucial role in the generation of these fluctuations. By tuning the propagation velocity in a network based on primate connectivity, we scale the time delays and demonstrate the emergence of the resting state networks for biophysically realistic parameters.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Assisi CG, Jirsa VK, Kelso JAS (2005) Synchrony and clustering in heterogeneous networks with global coupling and parameter dispersion. PRL 94:018106 Assisi CG, Jirsa VK, Kelso JAS (2005) Synchrony and clustering in heterogeneous networks with global coupling and parameter dispersion. PRL 94:018106
Zurück zum Zitat Bar M (2007) The proactive brain: using analogies and associations to generate predictions. Trends Cogn Sci 11(7):280–289CrossRefPubMed Bar M (2007) The proactive brain: using analogies and associations to generate predictions. Trends Cogn Sci 11(7):280–289CrossRefPubMed
Zurück zum Zitat Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537–541CrossRefPubMed Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537–541CrossRefPubMed
Zurück zum Zitat Breakspear M, Jirsa VK (2007) Neuronal dynamics and brain connectivity. In: Jirsa VK, McIntosh ARM (eds) Handbook of brain connectivity. Springer Breakspear M, Jirsa VK (2007) Neuronal dynamics and brain connectivity. In: Jirsa VK, McIntosh ARM (eds) Handbook of brain connectivity. Springer
Zurück zum Zitat Damoiseaux JS et al (2006) Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci USA 103:13848–13853CrossRefPubMed Damoiseaux JS et al (2006) Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci USA 103:13848–13853CrossRefPubMed
Zurück zum Zitat Daubechies I (1992) Ten lectures on wavelets. SIAM Daubechies I (1992) Ten lectures on wavelets. SIAM
Zurück zum Zitat FitzHugh R (1961) Impulses and physiological states in theoretical models of nerve membrane. Biophys J 1:445–466CrossRefPubMed FitzHugh R (1961) Impulses and physiological states in theoretical models of nerve membrane. Biophys J 1:445–466CrossRefPubMed
Zurück zum Zitat Fox MD et al (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 102:9673–9678CrossRefPubMed Fox MD et al (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 102:9673–9678CrossRefPubMed
Zurück zum Zitat Greicius MD, Krasnow B, Reiss AL, Menon V (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100:253–258CrossRefPubMed Greicius MD, Krasnow B, Reiss AL, Menon V (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100:253–258CrossRefPubMed
Zurück zum Zitat Gusnard DA, Raichle ME (2001) Searching for a baseline: Functional imaging and the resting human brain. Nat Rev Neurosci 2:685–694CrossRefPubMed Gusnard DA, Raichle ME (2001) Searching for a baseline: Functional imaging and the resting human brain. Nat Rev Neurosci 2:685–694CrossRefPubMed
Zurück zum Zitat Honey CJ, Kötter R, Breakspear M, Sporns O (2007) Network structure of cerebral cortex shapes function connectivity on multiple time scales. Proc Natl Acad Sci USA 104:10240–10245CrossRefPubMed Honey CJ, Kötter R, Breakspear M, Sporns O (2007) Network structure of cerebral cortex shapes function connectivity on multiple time scales. Proc Natl Acad Sci USA 104:10240–10245CrossRefPubMed
Zurück zum Zitat Jirsa VK (2004) Connectivity and dynamics of neural information processing. Neuroinformatics 2(2):183–204CrossRefPubMed Jirsa VK (2004) Connectivity and dynamics of neural information processing. Neuroinformatics 2(2):183–204CrossRefPubMed
Zurück zum Zitat Kötter R (2004) Online retrieval, processing, and visualization of primate connectivity data from the CoCoMac database. Neuroinformatics 2:127–144CrossRefPubMed Kötter R (2004) Online retrieval, processing, and visualization of primate connectivity data from the CoCoMac database. Neuroinformatics 2:127–144CrossRefPubMed
Zurück zum Zitat Kötter R (2005) Wanke Mapping brains without coordinates. Philos Trans R Soc Lond B 360:751–766CrossRef Kötter R (2005) Wanke Mapping brains without coordinates. Philos Trans R Soc Lond B 360:751–766CrossRef
Zurück zum Zitat Nagumo J, Arimoto S, Yoshizawa S (1962) An active pulse transmission line simulating nerve axon. Proc IRE 50:2061–2070CrossRef Nagumo J, Arimoto S, Yoshizawa S (1962) An active pulse transmission line simulating nerve axon. Proc IRE 50:2061–2070CrossRef
Zurück zum Zitat Salvador R, Achard S, Bullmore ET (2007) Frequency dependent functional connectivity analysis of fMRI data in Fourier and wavelet domains. In: Jirsa VK, McIntosh ARM (eds) Handbook of brain connectivity. Springer Salvador R, Achard S, Bullmore ET (2007) Frequency dependent functional connectivity analysis of fMRI data in Fourier and wavelet domains. In: Jirsa VK, McIntosh ARM (eds) Handbook of brain connectivity. Springer
Zurück zum Zitat Vincent JL et al (2006) Coherent spontaneous activity identifies a hippocampal-parietal memory network. J Neurophysiol 96:3517–3531CrossRefPubMed Vincent JL et al (2006) Coherent spontaneous activity identifies a hippocampal-parietal memory network. J Neurophysiol 96:3517–3531CrossRefPubMed
Zurück zum Zitat Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Van Essen DC, Zempel JM, Snyder LH, Corbetta M, Raichle ME (2007) Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447:83–86CrossRefPubMed Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Van Essen DC, Zempel JM, Snyder LH, Corbetta M, Raichle ME (2007) Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447:83–86CrossRefPubMed
Zurück zum Zitat Wilson HR, Cowan JD (1972) Excitatory and inhibitory interactions in localized populations of model neurons. Biophys J 12:1–23CrossRefPubMed Wilson HR, Cowan JD (1972) Excitatory and inhibitory interactions in localized populations of model neurons. Biophys J 12:1–23CrossRefPubMed
Metadaten
Titel
Cortical network dynamics with time delays reveals functional connectivity in the resting brain
verfasst von
A. Ghosh
Y. Rho
A. R. McIntosh
R. Kötter
V. K. Jirsa
Publikationsdatum
01.06.2008
Verlag
Springer Netherlands
Erschienen in
Cognitive Neurodynamics / Ausgabe 2/2008
Print ISSN: 1871-4080
Elektronische ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-008-9044-2

Weitere Artikel der Ausgabe 2/2008

Cognitive Neurodynamics 2/2008 Zur Ausgabe

Neuer Inhalt