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Cognitive Neurodynamics
Erschienen in: Cognitive Neurodynamics 1/2017

15.11.2016 | Review Paper

Disrupted development and imbalanced function in the global neuronal workspace: a positive-feedback mechanism for the emergence of ASD in early infancy

verfasst von: Chris Fields, James F. Glazebrook

Erschienen in: Cognitive Neurodynamics | Ausgabe 1/2017

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Abstract

Autism spectrum disorder (ASD) is increasingly being conceptualized as a spectrum disorder of connectome development. We review evidence suggesting that ASD is characterized by a positive feedback loop that amplifies small functional variations in early-developing sensory-processing pathways into structural and functional imbalances in the global neuronal workspace. Using vision as an example, we discuss how early functional variants in visual processing may be feedback-amplified to produce variant object categories and disrupted top-down expectations, atypically large expectation-to-perception mismatches, problems re-identifying individual people and objects, socially inappropriate, generally aversive emotional responses and disrupted sensory-motor coordination. Viewing ASD in terms of feedback amplification of small functional variants allows a number of recent models of ASD to be integrated with neuroanatomical, neurofunctional and genetic data.
Nächster Artikel Frequency shift in topography of spontaneous brain rhythms from childhood to adulthood

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Metadaten
Titel
Disrupted development and imbalanced function in the global neuronal workspace: a positive-feedback mechanism for the emergence of ASD in early infancy
verfasst von
Chris Fields
James F. Glazebrook
Publikationsdatum
15.11.2016
Verlag
Springer Netherlands
Erschienen in
Cognitive Neurodynamics / Ausgabe 1/2017
Print ISSN: 1871-4080
Elektronische ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-016-9419-8

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