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Determination of levodopa in the presence of uric acid using a ZnO nanoflower-modified indium tin oxide glass electrode

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Abstract

ZnO nanoflowers (ZnONFs) were synthesized by a simple hydrothermal method which is a convenient, environment-friendly, inexpensive process. The ZnONF suspension was sprayed onto the surface of ITO-coated glass (ZnONFs/ITO), which acts as the working electrode for the determination of levodopa by cyclic voltammetry and differential pulse voltammetry. The effect of reaction regents on the sizes of ZnONFs was investigated. The morphologies and structure of ZnONFs were characterized by scanning electron microscopy and X-ray diffraction analysis, respectively. The results show that the optimized length and diameter of ZnONFs are ~2.5 μm and 50 nm, respectively. The sensitivity and measured limit of detection of the ZnONFs/ITO electrode for levodopa are 0.10 μA/μM and 2.5 μM in the range of 2.5–40 μM, respectively. The electrode can accurately detect levodopa in the presence of uric acid. Meanwhile, the electrode shows good repeatability and stability.

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Acknowledgements

This work is supported by the Natural Science Foundation of Heilongjiang Province (LC2015020), Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China (2015192), the innovative talent fund of Harbin city (2016RAQXJ185), and Science Funds for the Young Innovative Talents of HUST (201604).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    Hong Yan Yue, Bao Wang, Shuo Huang, Xin Gao, Xuan Yu Lin, Long Hui Yao, En Hao Guan, Hong Jie Zhang & Shan Shan Song

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shuo Huang

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  1. Hong Yan Yue
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  2. Bao Wang
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  3. Shuo Huang
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  4. Xin Gao
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  5. Xuan Yu Lin
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  6. Long Hui Yao
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  7. En Hao Guan
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  8. Hong Jie Zhang
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  9. Shan Shan Song
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Correspondence to Hong Yan Yue.

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Highlights

1. ZnO nanoflowers/ITO electrode prepared by hydrothermal synthesis and spray deposition.

2. ZnO nanoflowers with three-dimensional and large surface areas.

3. Higher sensitivity of 0.10 μA μM−1 for the detection of levodopa.

4. Excellent selectivity to determine levodopa in the presence of uric acid.

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Yue, H.Y., Wang, B., Huang, S. et al. Determination of levodopa in the presence of uric acid using a ZnO nanoflower-modified indium tin oxide glass electrode. Ionics 23, 3479–3486 (2017). https://doi.org/10.1007/s11581-017-2153-3

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  • DOI: https://doi.org/10.1007/s11581-017-2153-3

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