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Electrochemical determination of uric acid in the presence of ascorbic acid by hybrid of ZnO nanorods and graphene nanosheets

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Abstract

ZnO nanorods and graphene foam were synthesized via hydrothermal synthesis and chemical vapor deposition, respectively. Hybrid of ZnO nanorods and graphene nanosheets was prepared by ultrasonic treatment. The hybrid was sprayed onto the ITO glass. The hybrid was characterized by scanning electron microscopy, X-ray diffraction, and Raman spectroscopy. The electrochemical properties of the hybrid were measured by cyclic voltammetry and differential pulse voltammetry. The results show that the diameter and length of ZnO nanorods are ~ 50 nm and 5 μm, respectively. Graphene nanosheets with high quality are made up of few layers and the sheet size is ~ 2 μm. The sensitivity of the hybrid for detection of uric acid is 0.3 μM μA−1 cm−2 in the range of 5~80 μM. The electrode can accurately detect uric acid in the presence of ascorbic acid. Meanwhile, the electrode also shows good repeatability and stability.

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Acknowledgements

This work is supported by the Natural Science Foundation of Heilongjiang Province (LC2015020), Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China (2015192), the Innovative Talent Fund of Harbin City (2016RAQXJ185), Science Funds for the Young Innovative Talents of HUST (201604), and Doctoral Scientific Research Fund of Heilongjiang Institute of Technology (2014BJ14).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    Qizhao Wang, Hongyan Yue, Xin Gao, Hong Zhang, Xuanyu Lin & Bao Wang

  2. Harbin Welding Institute, Harbin, 150028, People’s Republic of China

    Qizhao Wang

  3. School of Materials Science and Chemistry, Harbin Engineering University, Harbin, 150001, People’s Republic of China

    Qizhao Wang

  4. Heilongjiang Institute of Technology, Harbin, 150001, People’s Republic of China

    Jianjiao Zhang

  5. Research Institute for Nuclear Problems Belarusian State University, Minsk, Belarus

    Dzmitry Bychanok

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  1. Qizhao Wang
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  2. Hongyan Yue
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  3. Jianjiao Zhang
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  4. Xin Gao
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  5. Hong Zhang
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  7. Bao Wang
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  8. Dzmitry Bychanok
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Corresponding author

Correspondence to Hongyan Yue.

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Highlights

1. Novel hybrid of ZnO nanorods-graphene nanosheets was prepared.

2. The hybrid demonstrates a high sensitivity of 0.3 μA μM−1 cm−2 for the detection of uric acid.

3. The hybrid has excellent selectivity to determine uric acid in the presence of ascorbic acid.

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Wang, Q., Yue, H., Zhang, J. et al. Electrochemical determination of uric acid in the presence of ascorbic acid by hybrid of ZnO nanorods and graphene nanosheets. Ionics 24, 2499–2507 (2018). https://doi.org/10.1007/s11581-017-2379-0

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  • DOI: https://doi.org/10.1007/s11581-017-2379-0

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