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Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode

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Abstract

Voltammetric method for the determination of non-steroidal anti-inflammatory drug mesalazine (5-ASA) is presented for the first time using boron-doped diamond electrode (BDDE). 5-ASA provides one well-developed SWV oxidation peak at about −900 mV (vs. saturated silver/silver chloride reference electrode) on BDDE. Britton-Robinson buffer (pH 7.0) was chosen as an optimal supporting electrolyte for the determination of 5-ASA using square wave voltammetry (SWV). Parameters of SWV were developed and low limit of detection (7.0 × 10−7 mol L−1) was reached. In addition, relative standard deviation of repeated measurements (c 5-ASA = 5 × 10−5 mol L−1, RSDM = 2.7%) and relative standard deviation of repeated determinations (RSDD < 1.5%) were calculated and confirm obtained good results. Applicability of the proposed method was verified by an analysis of a pharmaceutical preparation and spiked human urine.

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Acknowledgements

This work was supported by the University of Pardubice (Project No. SGS_2017_002).

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Authors and Affiliations

  1. Institute of Environmental and Chemical Engineering, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic

    Michaela Štěpánková, Renáta Šelešovská, Lenka Janíková & Jaromíra Chýlková

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  1. Michaela Štěpánková
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  2. Renáta Šelešovská
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  3. Lenka Janíková
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  4. Jaromíra Chýlková
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Correspondence to Michaela Štěpánková.

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Štěpánková, M., Šelešovská, R., Janíková, L. et al. Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode. Chem. Pap. 71, 1419–1427 (2017). https://doi.org/10.1007/s11696-017-0135-6

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  • DOI: https://doi.org/10.1007/s11696-017-0135-6

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