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Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications

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Abstract

In the present work, nanocrystalline hydroxyapatite/alumina \((\hbox {HAp}{-}\hbox {Al}_{2}\hbox {O}_{3})\) composite was prepared under specially designed stir-type hydrothermal reactor. The composite was prepared at two different temperatures under autogenous pressure and analysed for crystallinity, size, shape, composition and thermomechanical stability. The electron microscopy study shows the formation of \(\hbox {HAp}{-}\hbox {Al}_{2}\hbox {O}_{3}\) composite nanorods with uniform distribution. The thermogravimetry analysis reveals better thermomechanical property with minimal weight loss at increased temperature. The effect of different concentrations of \(\hbox {HAp}{-}\hbox {Al}_{2}\hbox {O}_{3}\) composite powders against MG63 human osteosarcoma cell lines shows excellent compatibility (80%) at high concentration of \(200~\upmu \hbox {g ml}^{-1}\). These studies facilitate the formation of biocompatible \(\hbox {HAp}{-}\hbox {Al}_{2}\hbox {O}_{3}\) composite nanorods for biomedical applications.

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Acknowledgements

We are grateful to PSG institutions for providing necessary facilities to carry out the research. The author, S Vignesh Raj, is grateful to UGC National fellowship F./2014-15/NFO-2014-15-TAM-OBC-10405/ (SA-III website) for providing PhD assistantship. This work was financially supported by UGC MRP file. no. 42-867/2013 (SR).

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Authors and Affiliations

  1. Department of Biomedical Engineering, PSG College of Technology, Coimbatore, 641004, India

    S Vignesh Raj & A Kandaswamy

  2. Department of Physics, PSG College of Arts and Science, Coimbatore, 641014, India

    M Rajkumar

  3. Department of Physics, LRG Government Arts College for Women, Tiruppur, 641604, India

    N Meenakshi Sundaram

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  1. S Vignesh Raj
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  2. M Rajkumar
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  4. A Kandaswamy
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Correspondence to M Rajkumar.

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Vignesh Raj, S., Rajkumar, M., Meenakshi Sundaram, N. et al. Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications. Bull Mater Sci 41, 93 (2018). https://doi.org/10.1007/s12034-018-1612-4

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