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GC–MS Analysis of Bio-active Molecules Derived from Paracoccus pantotrophus FMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs

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Abstract

The present investigation is focused on the study of chemical composition of a bioactive compound derived from a rumen isolate Paracoccus pantotrophus FMR19 using GC–MS and to find out the antibacterial activity of the extracted crude bioactive compounds against multidrug resistant organisms (MDROs) and other clinical pathogens. GC–MS analysis revealed that P. pantotrophus FMR19 produced eight major compounds that have been reported to exhibit antimicrobial property. The main components identified from hexane fraction are long chain alkanes, fatty alcohols, fatty acid methyl ester and aromatic hydrocarbons. These molecules are not only active against clinical pathogens such as Salmonella sp. and Proteus sp. and also effective against MDROs such as Metallo β lactamase and Pan drug resistant bacterial strains and Methicillin resistant Staphylococcus aureus.

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Acknowledgments

The author I. Faridha Begum, Senior research Fellow is grateful for the financial assistance by University Grant Commision.

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Authors and Affiliations

  1. Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamilnadu, 603 203, India

    I. Faridha Begum & K. Ramani

  2. Interdisciplinary Institute of Indian System of Medicine, SRM University, Kattankulathur, Tamilnadu, 603 203, India

    R. Mohankumar

  3. Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Chennai, Tamilnadu, 600 069, India

    M. Jeevan

Authors
  1. I. Faridha Begum
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  2. R. Mohankumar
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  4. K. Ramani
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Correspondence to K. Ramani.

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Faridha Begum, I., Mohankumar, R., Jeevan, M. et al. GC–MS Analysis of Bio-active Molecules Derived from Paracoccus pantotrophus FMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs. Indian J Microbiol 56, 426–432 (2016). https://doi.org/10.1007/s12088-016-0609-1

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  • DOI: https://doi.org/10.1007/s12088-016-0609-1

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