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pharmaHUB: Building a Virtual Organization for Pharmaceutical Engineering and Science

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Abstract

Information technology and high-performance computing play a critical role in the development of virtual organizations for science and engineering disciplines. In this paper, we report on our efforts to design and develop pharmaHUB.org, a prototype virtual organization that intends to promote the joint creation and sharing of tools, knowledge, and educational materials across the various science and engineering disciplines related to pharmaceutical product development and manufacturing. pharmaHUB has been brought online using middleware from HUBzero which provides content management and community building capabilities and also makes it possible to deliver simulation tools through the web. By leveraging the HUBzero middleware and forming partnerships with existing communities of researchers, it has been possible to rapidly develop a prototype virtual organization with a significant offering of educational and simulation tool resources. Prototype tools to support the knowledge management needs of pharmaceutical development have also been integrated into the hub environment.

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References

  1. DeSanctis G, Monge P. Introduction to the special issue: communication processes for virtual organizations. Organ Sci. 1999;10(6):693–703.

    Article  Google Scholar 

  2. Wulf WA. The collaboratory opportunity. Science. 1993;261:854–5.

    Article  PubMed  CAS  Google Scholar 

  3. Hey T, Trefethen AE. Cyberinfrastructure for e-Science. Science. 2005;308:817–21.

    Article  PubMed  CAS  Google Scholar 

  4. O’Leary MB, Cummings JN. The spatial, temporal, and configurational characteristics of geographic dispersion in teams. MIS Quart. 2007;31(3):433–52.

    Google Scholar 

  5. Cummings J, Finholt T, Foster I, Kesselman C, Lawrence KA. (2008) Beyond being there: a blueprint for advancing the design, development, and evaluation of virtual organizations. Final Report from Workshops on Building Effective Virtual Organizations. National Science Foundation.

  6. Foster I, Kesselman C, Tuecke S. The anatomy of the grid: enabling scalable virtual organizations. Int J High Perform C. 2001;15(3):200–22.

    Article  Google Scholar 

  7. Lundstrom M, Klimeck G. (2006) The NCN: science, simulation, and cyber services. IEEE Conference on Emerging Technologies—Nanoelectronics, p. 496–500.

  8. Klimeck G, McLennan M, Brophy SP, Adams GB, Lundstrom MS. nanoHUB.Org: advancing education and research in nanotechnology. Comput Sci Eng. 2008;10(5):17–23.

    Article  CAS  Google Scholar 

  9. Fortes AB, Figueiredo J, Lundstrom MS. Virtual computing infrastructures for nanoelectronics simulation. P IEEE. 2005;93(10):1839–47.

    Article  Google Scholar 

  10. Adabala S, Chadha V, Chawla P, Figueiredo R, Fortes J, Krsul I, et al. From virtualized resources to virtual computing grids: the In-VIGO system. Future Gener Comput Syst. 2005;21(6):896–909.

    Article  Google Scholar 

  11. Epema DHJ, Livny M, van Dantzig R, Evers X, Pruyne J. A worldwide flock of condors: load sharing among workstation clusters. Future Gener Comput Syst. 1996;12(1):53–65.

    Article  Google Scholar 

  12. Thain D, Tannenbaum T, Livny M. Distributed computing in practice: the Condor experience. Concur Comp-Pract E. 2005;17(2–4):323–56.

    Article  Google Scholar 

  13. Qiao W, McLennan M, Kennell R, Ebert D, Klimeck G. Hub-based simulation and graphics hardware accelerated visualization for nanotechnology applications. IEEE Trans Vis Comput Graph. 2006;12(5):1061–68.

    Article  PubMed  Google Scholar 

  14. Cooper K, Gupta A, Beaudoin S. Simulation of the adhesion of particles to surfaces. J Colloid Interface Sci. 2001;234(2):284–92.

    Article  PubMed  CAS  Google Scholar 

  15. Portillo P, Muzzio F, Ierapetritou M. Using compartment modeling to investigate mixing behavior of a continuous mixer. J Pharm Innovation. 2008;3(3):161–74.

    Article  Google Scholar 

  16. Johanson JR. A rolling theory for granular solids. J Appl Mech. 1965;32(4):842–8.

    CAS  Google Scholar 

  17. Braido D, Cuitino A. (2008) Modeling of tablet dissolution attendant to tablet microstructure using a multi-process F-D method. AIChE Annual Meeting, Philadelphia.

  18. Hartman P, Perdok WG. On the relations between structure and morphology of crystals. I. Acta Crystallogr. 1955;8:49–52.

    Article  CAS  Google Scholar 

  19. Bennema P, Meekes H, Boerrigter SXM, Cuppen HM, Deij MA, van Eupen J, et al. Crystal growth and morphology: new developments in an integrated Hartman–Perdok connected net roughening transition theory, supported by computer simulations. Crystal Growth Des. 2004;4(5):905–13.

    Article  CAS  Google Scholar 

  20. Venkatasubramanian V, Zhao C, Joglekar G, Jain A, Hailemariam L, Suresh P, et al. Ontological informatics infrastructure for pharmaceutical product development and manufacturing. Comput Chem Eng. 2006;30(10–12):1482–96.

    Article  CAS  Google Scholar 

  21. Zhao C, Jain A, Hailemariam L, Suresh P, Akkisetty P, Joglekar G, et al. Towards intelligent decision support for pharmaceutical product development. J Pharm Innovation. 2006;1:23–36.

    Article  Google Scholar 

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Acknowledgment

The development of pharmaHUB has been supported by a grant from the National Science Foundation (award no. 0742760). The authors wish to acknowledge the assistance in the design and development of pharmaHUB provided by the HUBzero team including Michael McLennan, George Howlett, Derrick Kearney, Nicholas Kisseberth, Shawn Rice and Swaroop Shivarajapura.

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Authors and Affiliations

  1. Pharmaceutical Technology & Education Center, Purdue University, West Lafayette, IN, 47907, USA

    Kamal Kuriyan & Gintaras V. Reklaitis

  2. Rosen Center for Advanced Computing, Purdue University, West Lafayette, IN, 47907, USA

    Ann Christine Catlin

Authors
  1. Kamal Kuriyan
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  2. Ann Christine Catlin
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  3. Gintaras V. Reklaitis
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Correspondence to Kamal Kuriyan.

Additional information

Using recent developments in web middleware to promote the joint creation and sharing of tools, knowledge, and educational materials in pharmaceutical engineering and science

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Kuriyan, K., Catlin, A.C. & Reklaitis, G.V. pharmaHUB: Building a Virtual Organization for Pharmaceutical Engineering and Science. J Pharm Innov 4, 81–89 (2009). https://doi.org/10.1007/s12247-009-9061-7

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  • DOI: https://doi.org/10.1007/s12247-009-9061-7

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