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Abwehr gegen Fremd-DNA durch das bakterielle CRISPR/Cas-System

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  • Mikrobielles „Immunsystem“
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BIOspektrum Aims and scope

Zusammenfassung

Kurze Fremd-DNA-Sequenzen werden in bakterielle Genome integriert (CRISPR-Arrays) und dienen nach Transkription und Prozessierung zusammen mit einem Set konservierter Proteine (Cas-Proteine) zur Identifikation und Elimination von eingedrungener DNA.

Abstract

Short foreign DNA sequences are integrated in bacterial genomes (CRISPR arrays), where they operate after transcription and processing together with a set of conserved proteins (Cas proteins) to target and destroy DNA that had invaded the cell.

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Authors and Affiliations

  1. Molekularbiologie der Bakterien, Universität Düsseldorf, Düsseldorf, Germany

    Rolf Wagner & Ümit Pul

  2. Institut für Physikalische Biologie Molekularbiologie der Bakterien, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D-40225, Düsseldorf, Germany

    Rolf Wagner & Ümit Pul

Authors
  1. Rolf Wagner
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  2. Ümit Pul
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Correspondence to Rolf Wagner or Ümit Pul.

Additional information

Ümit Pul Jahrgang 1977. Biologiestudium an der Universität Düsseldorf, 2008 Promotion mit Schwerpunkt Molekularbiologie der Bakterien in der Arbeitsgruppe von Prof. Dr. Wagner. Seit 2010 Leiter einer unabhängigen Arbeitsgruppe zur Analyse der Struktur und Funktion des CRISPR/Cas-Systems.

Rolf Wagner Jahrgang 1948. Chemiestudium an den Universitäten Marburg und Münster. 1976 Promotion bei Prof. Dr. Gassen. Postdoc am Max-Planck-Institut für Molekulare Genetik, Berlin. Ab 1979 Arbeitsgruppenleiter am MPI für Molekulare Genetik. 1983 Habilitation in Molekularbiologie, FU Berlin. Ab 1986 Heisenberg-Stipendiat. Seit 1987 Professor an der Universität Düsseldorf.

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Wagner, R., Pul, Ü. Abwehr gegen Fremd-DNA durch das bakterielle CRISPR/Cas-System. Biospektrum 17, 393–395 (2011). https://doi.org/10.1007/s12268-011-0059-6

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  • DOI: https://doi.org/10.1007/s12268-011-0059-6

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