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Application of magnetic nanoparticle for controlled tissue assembly and tissue engineering

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Abstract

Magnetic nanoparticles have been subjected to extensive studies in the past few decades owing to their promising potentials in biomedical applications. The versatile intrinsic properties of magnetic nanoparticles enable their use in many biomedical applications. Recently, magnetic nanoparticles were utilized to control the cell’s function. In addition, intracellular delivery of magnetic nanoparticles allowed cell’s positioning by appropriate use of magnetic field and created cellular cluster. Furthermore, magnetic nanoparticles have been utilized to assemble more complex tissue structures than those that are achieved by conventional scaffold-based tissue engineering strategies. This review addresses recent work in the use magnetic nanoparticle for controlled tissue assembly and complex tissue formation.

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Acknowledgments

This work was supported by SNU Engineering-Medicine Cooperation Research Grant and Research Settlement Fund for new faculty of SNU. This research was also supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2013071521).

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Authors and Affiliations

  1. School of Chemical and Biological Engineering, Institute for Chemical Processing, Seoul National University, 1 Gwanak-gu, Gwanak-ro, Seoul, 151-744, Republic of Korea

    Eunjee A. Lee, Hyungu Yim, Jiseung Heo, Hwan Kim, Giyoung Jung & Nathaniel S. Hwang

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  1. Eunjee A. Lee
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  2. Hyungu Yim
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  3. Jiseung Heo
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  4. Hwan Kim
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Correspondence to Nathaniel S. Hwang.

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Lee, E.A., Yim, H., Heo, J. et al. Application of magnetic nanoparticle for controlled tissue assembly and tissue engineering. Arch. Pharm. Res. 37, 120–128 (2014). https://doi.org/10.1007/s12272-013-0303-3

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