Skip to main content

Advertisement

Log in

Preparation of Food Flavor Nanoemulsions by High- and Low-Energy Emulsification Approaches

  • Published:
Food Engineering Reviews Aims and scope Submit manuscript

Abstract

Flavor ingredients are major contributors to the profile of food products. As these components are mostly volatile and hydrophobic, achieving their enhanced bioaccessibility and controlled release during processing is of utmost concern to food manufacturers. Emulsions prepared at nanoscale (2–200 nm) not only give the opportunity to protect the flavor ingredients but also enable achieving higher homogeneity in the emulsion system through produced smaller droplet size. Among developed approaches of high and low energy for preparation of flavor nanoemulsions, low-energy approaches give the possibility to develop nanoemulsions in absence of high shear and pressure, and are suitable selections for preparation of nanoemulsions for thermal-sensitive flavor components with the requirement of consuming less energy in comparison to high-energy methods. However, limitation of using synthetic surfactants might limit their applications for food systems and high amount of surfactant might be necessary to produce stable nanoemulsions with small droplet sizes. Preparation of nanoemulsions for encapsulation of food flavors applying low-energy methods is considered as a new emerging approach with potential for further research for development of ingredients applicable in food formulations and production of stable nanoemulsions at large scale. Considering the growing demand for food flavors, this review aims to highlight recent advancements in the application of high- and low-energy approaches for preparation of flavor nanoemulsions with the focus on discussing the main factors influencing stability and particle size of prepared nanoemulsions during development and storage and can provide insights on further production of nanoemulsions at an industrial large scale.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Abbas S, Bashari M, Akhtar W, Li WW, Zhang X (2014) Process optimization of ultrasound-assisted curcumin nanoemulsions stabilized by OSA-modified starch. Ultrason Sonochem 21(4):1265–1274

    CAS  PubMed  Google Scholar 

  2. Abbas S, Karangwa E, Bashari M, Hayat K, Hong X, Sharif HR, Xiaoming Z (2015) Fabrication of polymeric nanocapsules from curcumin-loaded nanoemulsion templates by self-assembly. Ultrason Sonochem 23:81–92

    CAS  PubMed  Google Scholar 

  3. Akbas E (2016) Design and characterization of capsaicin loaded nanoemulsions. Middle East Technical University

  4. Akbas E, Soyler B, Oztop MH (2018) Formation of capsaicin loaded nanoemulsions with high pressure homogenization and ultrasonication. LWT- Food Sci Technol 96:266–273

    CAS  Google Scholar 

  5. Akoh CC, Min DB (2007) Food lipids, chemistry, nutrition, and biotechnology. Taylor & Ftancis Group L.L.C, Boca Raton

    Google Scholar 

  6. Alliod O, Valour J-P, Urbaniak S, Fessi H, Dupin D, Charcosset C (2018) Preparation of oil-in-water nanoemulsions at large-scale using premix membrane emulsification and Shirasu porous glass (SPG) membranes. Colloid Surfaces A 557:76–84

    CAS  Google Scholar 

  7. Araiza-Calahorra A, Akhtar M, Sarkar A (2018) Recent advances in emulsion-based delivery approaches for curcumin: from encapsulation to bioaccessibility. Trends Food Sci Tech 71:155–169

    CAS  Google Scholar 

  8. Arancibia C, Riquelme N, Zuniga R, Matiacevich S (2017) Comparing the effectiveness of natural and synthetic emulsifiers on oxidative and physical stability of avocado oil-based nanoemulsions. Innov Food Sci Emerg 44:159–166

    CAS  Google Scholar 

  9. Artiga-Artigas M, Acevedo-Fani A, Martin-Belloso O (2017) Effect of sodium alginate incorporation procedure on the physicochemical properties of nanoemulsions. Food Hydrocolloid 70:191–200

    CAS  Google Scholar 

  10. Artiga-Artigas M, Lanjari-Perez Y, Martin-Belloso O (2018) Curcumin-loaded nanoemulsions stability as affected by the nature and concentration of surfactant. Food Chem 266:466–474

    CAS  PubMed  Google Scholar 

  11. Asmawati M, W WA, Yusop SM, Maskat MY, Shamsuddin AF (2014) Characteristics of cinnamaldehyde nanoemulsion prepared using APV-high pressure homogenizer and ultra turrax. In: AIP Conf Proc, vol 1614. AIP Publishing LLC, pp 244–250

  12. Aulton, ME, & Taylor, KMG (2013) Aulton’s pharmaceutics, the design and manufacture of medicines (Fourth ed.): Elsevier Health Sciences

  13. BASF (2019) Kolliphor RH40, Non-ionic oil-in-water solubilizer and emulsifying agent. BASF https://pharmaceutical.basf.com/en/Drug-Formulation/Kolliphor-RH40.html. Accessed 22 May 2019

  14. Bermudez-Aguirre, D. (2017). Ultrasound: advances in food processing and preservation: Elsevier Inc.

  15. Bilbao-Sainz C, Avena-Bustillos RJ, Wood DF, Williams TG, McHugh TH (2010) Nanoemulsions prepared by a low-energy emulsification method applied to edible films. J Agric Food Chem 58(22):11932–11938

  16. Binks BP, Horozov TS (2006) Colloidal particles at liquid interfaces. Cambridge University Press

  17. Borrin TR, Georges EL, Moraes ICF, Pinho SC (2016) Curcumin-loaded nanoemulsions produced by the emulsion inversion point (EIP) method: an evaluation of process parameters and physico-chemical stability. J Food Eng 169:1–9

    CAS  Google Scholar 

  18. Brooks BW, Richmond HN (1994) Phase inversion in non-ionic surfactant-oil-water systems-II. Drop size studies in catastrophic inversion with turbulent mixing. Chem Eng Sci 49(7):1065–1075

    CAS  Google Scholar 

  19. CAC/GL. (2008). Guidelines for the use of flavourings. In (Vol. 66, pp. 1-3): Codex Alimentarius Commission. http://www.maff.go.jp/j/shokusan/seizo/pdf/66-2008.pdf. Accessed 9 May 2019

  20. Calligaris S (2018) Combined high-power ultrasound and high-pressure homogenization nanoemulsification: the effect of energy density, oil content and emulsifier type and content. Food Res Int 107:700–707

    CAS  PubMed  Google Scholar 

  21. Capdevila M, Maestro A, Porras M, Gutierrez JM (2010) Preparation of Span80/oil/water highly concentrated emulsions: influence of composition and formation variables and scale-up. J Colloid Interf Sci 345(1):27–33

    CAS  Google Scholar 

  22. CFR (2019a) Part 175.5 Exemptions, subpart A- general provisions. In: Food and Drug Administration, Department of Health and Human Services. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=117.5. Accessed 30 May 2019

  23. CFR (2019b) Part 182.10, subpart A- spices and other natural seasonings and flavorings. In (Vol. Title 21, Subchapter B): Food and Drug Administration, Department of Health and Human Services. https://www.ecfr.gov/cgi-bin/text-idx?SID=ccfee744667ebb74ad9a401863d23215&mc=true&node=se21.3.182_110&rgn=div8. Accessed 24 May 2019

  24. CFR (2019c). Part 182.70, subpart A- substances migrating from cotton and cotton fabrics used in dry food packaging. In (Vol. Title 21, Subchapter B): Food and Drug Administration, Department of Health and Human Services. https://www.ecfr.gov/cgi-bin/text-idx?SID=0507b12519fe780fe3d9ec16e4b99b0b&mc=true&node=se21.3.182_170&rgn=div8. Accessed 24 May 2019

  25. CFR (2019d) Part 184.1555 Rapessed oil, part 184, subpart B- directed food substances affirmed as generally recognized as safe. In (Vol. Title 21, Subchapter B): Food and Drug Administration, Department of Health and Human Services. https://www.ecfr.gov/cgi-bin/text-idx?SID=623076aca41aecca37fa7a64035b0eed&mc=true&node=se21.3.184_11555&rgn=div8. Accessed 24 May 2019

  26. CFR (2019e) Part 582.10, subpart A- spices and other natural seasonings and flavorings. In Code of Federal Regulations, Subpart A: General provisions (Vol. Title 21, Volume 6): Food and Drug Administration, Department of Health and Human Services. https://www.ecfr.gov/cgi-bin/text-idx?SID=f8e67f5bd9e1710dd55adc86e67829e5&mc=true&node=se21.6.582_110&rgn=div8. Accessed 24 May 2019

  27. CFR (2019f) Part 582.20, subpart A- essential oils, oleoresins (solvent-free), and natural extractives (including distillates). In Code of Federal Regulations, Subpart A: General provisions (Vol. Title 21, Volume 6): Food and drug administration, Department of Health and Human Services. https://www.ecfr.gov/cgi-bin/text-idx?SID=f8e67f5bd9e1710dd55adc86e67829e5&mc=true&node=se21.6.582_120&rgn=div8. Accessed 23 May 2019

  28. CFR (2019g) Part 582.40, subpart A- natural extractives (solvent-free) used in conjunction with spices, seasonings, and flavorings. In: Food and Drug Administration, Department of Health and Human Services. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=582.40. Accessed 24 May 2019

  29. CFR (2019h) Part 582.60, subpart A- synthetic flavoring substances and adjuvants. In Code of Federal Regulations, Subpart A: General provisions (Vol. Title 21, volume 6): Food and Drug Administration, Department of Health and Human Services. https://www.ecfr.gov/cgi-bin/text-idx?SID=f8e67f5bd9e1710dd55adc86e67829e5&mc=true&node=se21.6.582_160&rgn=div8. Accessed 23 May 2019

  30. Chang Y, McClements DJ (2014) Optimization of orange oil nanoemulsion formation by isothermal low-energy methods: influence of the oil phase, surfactant, and temperature. J Agric Food Chem 62(10):2306–2312

    CAS  PubMed  Google Scholar 

  31. Chang Y, McLandsborough L, McClements DJ (2013) Physicochemical properties and antimicrobial efficacy of carvacrol nanoemulsions formed by spontaneous emulsification. J Agric Food Chem 61(37):8906–8913

    CAS  PubMed  Google Scholar 

  32. Chaudhury A, Das S (2014) Chitosan derivatives for oral delivery of insulin. In: Kim S-K (ed) Chitin and chitosan derivatives, advances in drug discovery and developments. Taylor & Francis Groip, LLC., Boca Raton, FL

  33. ChemAxon. (2019). https://chemaxon.com/. Accessed 11 February 2019.

  34. Cid-Perez TS, Nevarez-Moorillon GV, Torres-Munoz JV, Palou E, Lopez-Malo A (2016) Mexican oregano (Lippia berlandieri and Poliomintha longiflora) oils. In: Preedy VR (ed) Essential oils in food preservation, flavor and safety. Elsevier Inc.

  35. CX/FAC (2004) JOINT FAO/WHO FOOD STANDARDS PROGRAMME CODEX COMMITTEE ON FOOD ADDITIVES AND CONTAMINANTS. In: Food and Agriculture Organization of the United Nations. World Health Organization http://www.fao.org/tempref/codex/Meetings/CCFAC/ccfac37/FA37_15e.pdf. Accessed 9 May 2019

  36. Davies JT (1985) Drop sizes of emulsions related to turbulent energy dissipation rates. Chem Eng Sci 40(5):839–842

    CAS  Google Scholar 

  37. Davies JT (1987) A physical interpretation of drop sizes in homogenizers and agitated tanks, including the dispersion of viscous oils. Chem Eng Sci 42(7):1671–1676

    CAS  Google Scholar 

  38. Dickinson E (1997) Properties of emulsions stabilized with milk proteins: overview of some recent developments. J Dairy Sci 80(10):2607–2619

    CAS  Google Scholar 

  39. Donsi F, Annunziata M, Sessa M, Ferrari G (2011) Nanoencapsulation of essential oils to enhance their antimicrobial activity in foods. LWT- Food Sci Technol 44:1908–1914

    CAS  Google Scholar 

  40. Estevinho BN, Rocha F (2017) A key for the future of the flavors in food industry. In: Oprea AE, Grumezescu AM (eds) Nanotechnology applications in food. Elsevier Inc., pp 1–19

  41. Flanagan J, Singh H (2006) Microemulsions: a potential delivery system for bioactives in food. Crit Rev Food Sci 46:221–237

    CAS  Google Scholar 

  42. Fleer GJ, Cohen Stuart MA, Scheutjens MHM, Cosgrove T, Vincent B (1995) Polymers at interfaces. Chapman & Hall, UK

    Google Scholar 

  43. Floury J, Legrand J, Desrumaux A (2004) Analysis of a new type of high pressure homogeniser. Part B. study of droplet break-up and recoalescence phenomena. Chem Eng Sci 59(6):1285–1294

    CAS  Google Scholar 

  44. Forgiarini A, Esquena J, Gonzalez C, Solans C (2001) Formation of nanoemulsions by low-energy emulsification methods at constant temperature. Langmuir 17(7):2076–2083

    CAS  Google Scholar 

  45. Galindo-Alvarez J, Sadtler V, Chopin L, Salager J-L (2011) Viscous oil emulsion by catastrophic phase inversion: influence of oil viscosity and process conditions. Ind Eng Chem Res 50(9):5575–5583

    CAS  Google Scholar 

  46. Ganachaud F, Katz JL (2005) Nanoparticles and nanocapsules created using the ouzo effect: spontaneous emulsification as an alternative to ultrasonic and high-shear devices. Phys Chem Chem Phys 6(2):209–216

    CAS  Google Scholar 

  47. Garti N, Benichou A (2001) Double emulsions for controlled-release applications-progress and trends. In: Sjoblom J (ed) Encyclopedic handbook of emulsion technology. CRC Press

  48. Gaulin. (2019). Gaulin homogenizer. In (Vol. 2019): DE Gaulin. http://gaulinhomogenizer.com/. Accessed 17 May 2019.

  49. Ghosh V, Saranya S, Mukherjee A, Chandrasekaran N (2013) Cinnamon oil nanoemulsion formulation by ultrasonic emulsification: investigation of its bactericidal activity. J Nanosci Nanotechno 13:114–122

    CAS  Google Scholar 

  50. Grumezescu, A. M. (2016a). Emulsions: Elsevier Inc.

    Google Scholar 

  51. Grumezescu AM (2016b) Encapsulations, nanotechnology in the agri-food industry, vol 2. Elsevier Inc., UK

    Google Scholar 

  52. Grumezescu, A. M., & Elena Oprea, A. (2017). Nanotechnology applications in food: flavor, stability, nutrition and safety: Elsevier Inc.

    Google Scholar 

  53. Gupta A, Eral HB, Hatton TA, Doyle PS (2016a) Controlling and predicting droplet size of nanoemulsions: scaling relations with experimental validation. Soft Matter 12(5):1452–1458

    CAS  PubMed  Google Scholar 

  54. Gupta A, Eral HB, Hatton TA, Doyle PS (2016b) Nanoemulsions: formation, properties and applications. Soft Matter 12(11):2826–2841

    CAS  PubMed  Google Scholar 

  55. Gupta A, Badruddoza AZM, Doyle PS (2017) A general route for nanoemulsion synthesis using low-energy methods at constant temperature. Langmuir 33:7118–7123

    CAS  PubMed  Google Scholar 

  56. Guttoff M, Saberi AH, McClements DJ (2014) Formation of vitamin D nanoemulsion-based delivery systems by spontaneous emulsification: factors affecting particle size and stability. Food Chem 171:117–122

    PubMed  Google Scholar 

  57. Hait SK, Moulik SP (2001) Determination of critical micelle concentration (CMC) of nonionic surfactants by donor-acceptor interaction with iodine and correlation of CMC with hydrophile-lipophile balance and other parameters of the surfactants. J Surfactants Deterg 4(3):303–309

    CAS  Google Scholar 

  58. Hall S (2012) Rules of thumb for chemical engineers, Fifth edn. Elsevier Inc., USA

    Google Scholar 

  59. Harborne JB, Baxter H (2001) Chemical dictionary of economic plants. Wiley, UK

    Google Scholar 

  60. Hasan HM, Leanpolchareanchai J, Jintapattanakit A (2015) Preparation of virgin coconut oil nanoemulsions by phase inversion temperature method. Adv Mater Res 1060:99–102

    Google Scholar 

  61. Heldman DR (2003) Encyclopedia of agricultural, food, and biological engineering. Marcel Dekker Inc., USA

    Google Scholar 

  62. Hierrezuelo JM, Molina-Bolivar JA, Carnero Ruiz C (2014) An energetic analysis of the phase separation in non-ionic surfactant mixtures: the role of the headgroup structure. Entropy 16(8):4375–4391

    CAS  Google Scholar 

  63. Hinze JO (1955) Fundamentals of the hydrodynamic mechanism of splitting in dispersion processes. AICHE J 1(3):289–295

    CAS  Google Scholar 

  64. Hostettmann K (2014) Handbook of chemical and biological plant analytical methods. Wiley, UK

    Google Scholar 

  65. Imran M, Butt MS, Suleria HAR (2017) Capsicum annum bioactive compounds: health promotion perspectives. In: Merillon J-M, Ramawat KG (eds) Bioactive molecules in food. Springer

  66. Jafari SM, He Y (2006) Nano-emulsions production by sonication and microfluidization- a comparison. Int J Food Prop 9:475–485

    CAS  Google Scholar 

  67. Jafari SM, McClements DJ (2018) Nanoemulsions: formulation, applications, and characterization. Elsevier Inc., India

    Google Scholar 

  68. Jafari SM, Assadpoor E, He Y, Bhandari B (2008) Re-coalesence of emulsion droplets during high-energy emulsification. Food hydrocolloid 22(7):1191–1202

    CAS  Google Scholar 

  69. Jintapattanakit A (2018) Preparation of nanoemulsions by phase inversion temperature (PIT) method. Pharm Sci Asia 45(1):1–12

    CAS  Google Scholar 

  70. Joung HJ, Choi MJ, Kim JT, Park SH, Park HJ, Shin GH (2016) Development of food-grade curcumin nanoemulsion and its potential application to food beverage system: antioxidant property and in vitro digestion. J Food Sci 81(3):N745–N753

    CAS  PubMed  Google Scholar 

  71. Karsa DR (1999) Design and selection of performance surfactants, annual surfactants review. Sheffield Academic Press, UK

    Google Scholar 

  72. Kim S-H, Ji Y-S, Lee E-S, Hong S-T (2016) Ostwald ripening stability of curcumin-loaded MCT nanoemulsion: influence of various emulsifiers. Prev Nutr Food Sci 21(3):289–295

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Klucker MF, Dalencon F, Probeck P, Haensler J (2012) AFO3, an alternative squalene emulsion-based vaccine adjuvant prepared by a phase inversion temperature method. J Pharm Sci 101(12):4490–4500

    PubMed  Google Scholar 

  74. Komaiko J (2016) Optimization of the fabrication, stability, and performance of food grade nanoemulsions with low and high energy methods. University of Massachusetts Amherst, USA

    Google Scholar 

  75. Komaiko J, McClements DJ (2014) Optimization of isothermal low-energy nanoemulsion formation: hydrocarbon oil, non-ionic surfactant, and water systems. J Colloid Interf Sci 425:59–66

    CAS  Google Scholar 

  76. Komaiko J, McClements DJ (2015) Low-energy formation of edible nanoemulsions by spontaneous emulsification: factors influencing particle size. J Food Eng 146:122–128

    CAS  Google Scholar 

  77. Komaiko J, McClements DJ (2016) Formation of food-grade nanoemulsions using low-energy preparation methods: a review of available methods. Compr Rev Food Sci F 15:331–352

    CAS  Google Scholar 

  78. Kronberg B, Holmberg K, Lindman B (2014) Surface chemistry of surfactants and polymers. Wiley, India

    Google Scholar 

  79. Kumar N, Mandal A (2018) Thermodynamic and physicochemical properties evaluation for formation and characterization of oil-in-water nanoemulsion. J Mol Liq 266:147–159

    CAS  Google Scholar 

  80. Kwan A, Davidov-Padro G (2018) Controlled release of flavor oil nanoemulsions encapsulated in filled soluble hydrogels. Food Chem 250:46–53

    CAS  Google Scholar 

  81. Lamba H, Sathish K, Sabikhi L (2015) Double emulsions: emerging delivery system for plant bioactives. Food Bioprocess Technol 8(4):709–728

    CAS  Google Scholar 

  82. Leal-Calderon, F, Schmitt, V, & Bibette, J (2007) Emulsion science, basic principles: Springer Science+Business Media, LLC

  83. Lee L, Norton IT (2013) Comparing droplet breakup for a high-pressure valve homogeniser and a microfluidizer for the potential production of food-grade nanoemulsions. J Food Eng 114(2):158–163

    CAS  Google Scholar 

  84. Leong TS, Wooster TJ, Kentish TJ, Ashokumar M (2009) Minimising oil droplet size using ultrasonic emulsification. Ultrason Sonochem 16(6):721–727

    CAS  PubMed  Google Scholar 

  85. Li Y, Zhang Z, Yuan Q, Liang H, Vriesekoop F (2013) Process optimization and stability of D-limonene nanoemulsions prepared by catastrophic phase inversion method. J Food Eng 119(3):419–424

    CAS  Google Scholar 

  86. Li J, Hwang I-C, Chen X, Park HJ (2016) Effects of chitosan coating on curcumin loaded nanoemulsion study on stability and in vitro digestibility. Food Hydrocolloid 60:138–147

    CAS  Google Scholar 

  87. Liang R, Shoemaker CF, Yang X, Zhong F, Huang Q (2013) Stability and bioaccessibility of β-carotene in nanoemulsions stabilized by modified starches. J Agric Food Chem 61(6):1249–1257

    CAS  PubMed  Google Scholar 

  88. Lu WC, Huang DW, Wang CR, Yeh CH, Tsai JC, Huang YT, Li PH (2018) Preparation, characterization, and antimicrobial activity of nanoemulsions incorporating citral essential oil. J Food Drug Anal 26(1):82–89. https://doi.org/10.1016/j.jfda.2016.12.018

    Article  CAS  PubMed  Google Scholar 

  89. Ma P, Zeng Q, Tai K, He X, Yao Y, Hong X, Yuan F (2017) Preparation of curcumin-loaded emulsion using high pressure homogenization: impact of oil phase and concentration on physicochemical stability. LWT-Food Sci Technol 84:34–46

    CAS  Google Scholar 

  90. Maa Y-F, Hsu CC (1999) Performance of sonication and microfluidization for liquid-liquid emulsification. Pharm Dev Technol 4(2):233–240

    CAS  PubMed  Google Scholar 

  91. Maali A, Mosavian MTH (2013) Preparation and application of nanoemulsions in the last decade (2000–2010). J Disper Sci Technol 34(1):92–105

    CAS  Google Scholar 

  92. Mahdi ES, Sakeena MHF, Abdulkarim MF, Abdullah GZ, Sattar MA, Noor AM (2011) Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. Drug Des Dev Ther 5:311–323

    CAS  Google Scholar 

  93. MarketsAndMarkets. (2018a). Food flavors market by type (chocolate & browns, vanilla, fruits & nuts, dairy, spices), application (beverages, dairy, confectionery, bakery, meat, savory & snacks), origin (natural and artificial), form, and region - global forecast to 2023. In (Vol. 2018): Markets and markets. https://www.marketsandmarkets.com/Market-Reports/food-flavors-market-93115891.html. Accessed 8 May 2019

  94. MarketsAndMarkets. (2018b). Microencapsulation market by technology (spray, emulsion, dripping), core material (pharma & healthcare drugs, PCM, food additives, fragrances), application (pharma, household, agrochemicals, textiles), shell material, and region - global forecast to 2023. In (Vol. 2019). https://www.marketsandmarkets.com/Market-Reports/microencapsulation-market-83597438.html. Accessed 9 May 2019.

  95. Mason TG, Graves SM, Wilking JN, Lin MY (2006) Extreme emulsification: formation and structure of nanoemulsions. Condens Matter Phys 9(1):193–199

    Google Scholar 

  96. Mattic LR, Rice AC (1976) Fatty acid composition of grape seed oil from native American and hybrid grape. Am J Enol Viticult 27(2):88–90

    Google Scholar 

  97. McBarron, J (2011) Curcumin: the 21st century cure: BookBaby

    Google Scholar 

  98. McClements DJ (1999) Food emulsions, principles, practice, and techniques. CRC Press LLC., USA

    Google Scholar 

  99. McClements DJ (2012) Advances in fabrication of emulsions with enhanced functionality using structural design principles. Curr opin Colloid In 17(5):235–245

    CAS  Google Scholar 

  100. McClements DJ (2015a) Food emulsions, principles, practices, and techniques, Third edn. Taylor & Francis Group LLC., Boca Raton

    Google Scholar 

  101. McClements DJ (2015b) Nanoparticle- and microparticle-based delivery systems: encapsulation, protection and release of active compounds. Taylor & Francis Group, LLC., Boca Raton

    Google Scholar 

  102. McClements DJ, Rao J (2011) Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci 51(4):285–330

    CAS  Google Scholar 

  103. Mitri K, Vauthier C, Huang N, Menas A, Ringard-Lefebvre C, Anselmi C, Stambouli M, Rosilio V, Vachon JJ, Bouchemal K (2012) Scale-up of nanoemulsion produced by emulsification and solvent diffusion. J Pharm Sci 101(11):4240–4247

    CAS  PubMed  Google Scholar 

  104. Muschiolik G, Dickinson E (2017) Double emulsions relevant to food systems: preparation, stability, and applications. Compr RevFood Sci F 16:532–555

    CAS  Google Scholar 

  105. Ng TB, Bekhit AE-D, Fang EF, Wong JH (2016) Chapter 51- grape seed (Vitis vinifera) oils. In: Preedy VR (ed) Essential oils in food preservation, flavor and safety. Elsevier Inc.

  106. Nguyen TTH, Si J, Kang C, Chung B, Chung D, KIm D (2017) Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides. Food Chem 214:366–373

    CAS  PubMed  Google Scholar 

  107. O’Brien RD (2009) Fats and oils: formulating and processing for applications, Third edn. Taylor & Francis Group LLC., Boca Raton

    Google Scholar 

  108. Olatunji O (2016) Natural polymers, industry techniques and applications. Springer International Publishing, Switzerland

    Google Scholar 

  109. Oliver, CM, & Augustin, MA (2009) 22- Using dairy ingredients for encapsulation. In M. Corredig (Ed.), Dairy-derived ingredients, food and nutraceutical uses: Woodhead Publishing

  110. Ostertag F, Weiss J, McClements DJ (2012) Low-energy formation of edible nanoemulsions: factors influencing droplet size produced by emulsion phase inversion. J Colloid Interf Sci 388(1):95–102

    CAS  Google Scholar 

  111. Ozturk B, Argin S, Ozilgen M, McClements DJ (2015) Nanoemulsions delivery systems for oil-soluble vitamins: influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility. Food Chem 187:499–506

    CAS  PubMed  Google Scholar 

  112. Panten J, Surburg H (2017) Flavors and fragrances, 4. Natural raw materials. In: Ulmann’s food and feed, vol 2. Wiley, Hamburg

    Google Scholar 

  113. Patel S (2015) Chapter 6- grape seeds: agro-industrial waste with vast functional food potential. In: Emerging bioresources with nutraceutical and pharmaceutical prospects. Springer International Publishing, Switzerland

    Google Scholar 

  114. Pattnaik S, Subramanyam VR, Bapaji M, Kole CR (1997) Antibacterial and antifungal activity of aromatic constituents of essential oils. Microbios 89(358):39–46

    CAS  PubMed  Google Scholar 

  115. Paul EL, Atiemo-Obeng VA, Kresta SM (2004) Handbook of industrial mixing, science and practice. Wiley, USA

    Google Scholar 

  116. Perez-Cordoba L, Norton IT, Batchelor HK, Gkatzionis K, Spyropoulos F, Sobral PJA (2018) Physicochemical antimicrobial and antioxidant properties of gelatin-chitosan based films loaded with nanoemulsions encapsulating active compounds. Food Hydrocolloid 79:544–559

    CAS  Google Scholar 

  117. Perry RH, Green DW (1998) Liquid-solid operations and equipment. In Perry’s chemical engineering handbook, Seventh edn. McGraw-Hill, Australia

    Google Scholar 

  118. Peshkovsky, AS (2017) Chapter 17- From research to production: overcoming scale-up limitations of ultrasonic processing. In D. Bermudez-Aguirre (Ed.), Ultrasound: advances for food processing and preservation: Elsevier Inc.

  119. Peshkovsky AS, Bystryak S (2014) Continuous-flow production of a pharmaceutical nanoemulsion by high-amplitude ultrasound: process scale-up. Chem Eng Process 82:132–136

    CAS  Google Scholar 

  120. Peshkovsky, S & Peshkovsky, AS (2014) High capacity ultrasonic reactor system. In (Vol. US 8,65,230 B2): Industrial Sonomechanics, LLC, New York, NY (US)

  121. Pey CM, Maestro A, Sole I, Gonzalez C, Solans C, Gutierrez JM (2006) Optimization of nano-emulsions prepared by low-energy emulsification methods at constant temperature using a factorial design study. Colloid Surface A 288:144–150

    CAS  Google Scholar 

  122. Pinheiro AC, Lad M, Silva HD, Coimbra MA, Boland M, Vicente AA (2013) Unravelling the behaviour of curcumin nanoemulsions during in vitro digestion: effect of the surface charge. Soft Matter 9:3147–3154

    CAS  Google Scholar 

  123. Pinheiro AC, Coimbra MA, Vicente AA (2016) In vitro behaviour of curcumin nanoemulsions stabilized by biopolymer emulsifiers – effect of interfacial composition. Food Hydrocolloid 52:460–467

    CAS  Google Scholar 

  124. Qian C, McClements DJ (2011) Formation of nanoemulsions stabilized by model food-grade emulsifiers using high-pressure homogenization: factors affecting particle size. Food Hydrocolloid 25(5):1000–1008

    CAS  Google Scholar 

  125. Qian C, Decker EA, Xiao H, McClements DJ (2012) Nanoemulsions delivery systems: influence of carrier oil on β-carotene bioaccessibility. Food Chem 135(3):1440–1447

    CAS  PubMed  Google Scholar 

  126. Rao J, McClements DJ (2010) Stabilization of phase inversion temperature nanoemulsions by surfactant displacement. Journal of Agricultural and Food Chem 58(11):7059–7066

    CAS  Google Scholar 

  127. Rao J, McClements DJ (2011a) Food-grade microemulsions, nanoemulsions and emulsions: fabrication from sucrose monopalmitate & lemon oil. Food Hydrocolloid 25(6):1413–1423

    CAS  Google Scholar 

  128. Rao J, McClements DJ (2011b) Formation of flavor oil microemulsions, nanoemulsions and emulsions: influence of composition and preparation method. J Agric Food Chem 59(9):55026–55035

    CAS  PubMed  Google Scholar 

  129. Raviadaran R, Ng MH, Manikham S, Chandran D (2019) Ultrasound-assisted water-in-palm oil nanoemulsion: influence of polyglycerol polyricinoleate and NaCl on its stability. Ultrason Sonochem 52:353–363

    CAS  PubMed  Google Scholar 

  130. Ray S, Mishra M, Mandal TK, Sa B, Chakraborty J (2015) Optimization of the process parameters for the fabrication of a polymer coated layered double hydroxide-methotrexate nanohybrid for the possible treatment of osteosarcoma. RSC Adv 5:102574–102592

    CAS  Google Scholar 

  131. Rayleigh L (1879) On the capillary phenomena of jets. Proc R Soc Lond 29:71–97

    Google Scholar 

  132. Reineccius G (1994) Source book of flavors, second edn. Springer Science+Business Media, Dordrecht

    Google Scholar 

  133. Rulison, C (2019) Surface tensiometry as a technique for the study of polymer/surfactant interactions in solution, aqueous solutions of non-ionic polymers and non-ionic surfactants. In. Hamburg, Germany: Krüss GmbH

  134. Sadeghi AMM, Dorkoosh FA, Avadi MR, Weinhold M, Bayat A, Delie F, Gurny R, Larijani B, Rafiee-Tehrani M, Junginger HE (2008) Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in CaCO-2 cells. Eur J Pharm Biopharam 70(1):270–278

    CAS  Google Scholar 

  135. Saffarionpour S, Ottens M (2018) Recent advances in techniques for flavor recovery in liquid food processing. Food Eng Rev 10(2):81–94

    CAS  Google Scholar 

  136. Sagitani H (1981) Making homogeneous and fine droplet O/W emulsions using nonionic surfactants. J Am Oil Chem Soc 58(6):738–743

    CAS  Google Scholar 

  137. Sajjadi S, jahanzad F, Brooks BW (2002) Phase inversion in abnormal O/W/O emulsions: I. Effect of surfactant concentration. Ind Eng Chem Res 41(24):6033–6041

    CAS  Google Scholar 

  138. Sajjadi S, jahanzad F, Yianneskis M, Brooks BW (2003) Phase inversion in abnormal O/W/O emulsions 2. Effect of surfactant hydrophilic-lipophilic-balance. Ind Eng Chem Res 42(15):3571–3577

    CAS  Google Scholar 

  139. Salvia-Trujillo L, Rojas-Graü A, Soliva-Fortuny R, Martin-Belloso O (2013a) Effect of processing parameters on physicochemical characteristics of microfluidized lemongrass essential oil-alginate nanoemulsions. Food Hydrocolloid 30(1):401–407

    CAS  Google Scholar 

  140. Salvia-Trujillo L, Rojas-Graü A, Soliva-Fortuny R, Martin-Belloso O (2013b) Physicochemical characterization of lemongrass essential oil-alginate nanoemulsions: effect of ultrasound processing parameters. Food Bioprocess Technol 6(9):2439–2446

    Google Scholar 

  141. Salvia-Trujillo L, Artiga-Artigas M, Molet-Rodriguez A, Turmo-Ibarz A, Martin-Belloso O (2018) Emulsion-based nanostructures for the delivery of active ingredients in foods. Front Sustain Food Syst 2(Article 79)

  142. Santana RC, Perrechil FA, Cunha RL (2013) High- and low-energy emulsifications for food applications: a focus on process parameters. Food Eng Rev 5(2):107–122

    CAS  Google Scholar 

  143. Saravacos GD, Kostaropoulos AE (2002) Handbook of food process equipment. Kluwer Academic/ Plenum Publishers, New York

    Google Scholar 

  144. Sari TP, Mann B, Kumar R, Singh RRB, Sharma R, Bjardwaj M, Athira S (2015) Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocolloid 43:540–546

    CAS  Google Scholar 

  145. Scholten E (2018) Engineered food microstructure for enhanced quality and stability: case study with emulsions and emulsion-filled gels. In: Devahastin S (ed) Food microstructure and its relationship with quality and stability. Elsevier Ltd., India

    Google Scholar 

  146. Sedaghat Doost A, Dewettinck K, Devlieghere F, Van der Meeren P (2018) Influence of non-ionic emulsifier type on the stability of cinnamaldehyde nanoemulsions: a comparison of polysorbate 80 and hydrophobically modified inulin. Food Chem 258:237–244

    CAS  PubMed  Google Scholar 

  147. Semenova M, Dickinson E (2010) Biopolymers in food colloids: thermodynamics and molecular interactions. Taylor & Francis Group LLC, Boca Raton

    Google Scholar 

  148. Shahidi, F (1997) Natural antioxidants, chemistry, health effects, and applications: The American Oil Chemists Society

  149. Sharif HR, Williams PA, Sharif MK, Khan MA, Majeed H, Safdar W, Shamoon M, Shaib M, Haider J, Zhong F (2017) Influence of OSA-starch on the physicochemical characteristics of flax seed oil-eugenol nanoemulsions. Food Hydrocolloid 66:365–377

    CAS  Google Scholar 

  150. Shinoda K, Saito H (1969) The stability of O/W type emulsions as functions of temperature and the HLB of emulsifiers: the emulsification by PIT- method. J Colloid Interf Sci 30(2):258–263

    CAS  Google Scholar 

  151. Sigmaaldrich. (2019). https://www.sigmaaldrich.com/nederland.html?gclid=EAIaIQobChMIqvqNpfy54gIV2eF3Ch2bxQ2EEAAYASAAEgLWQfD_BwE. Accessed 26 May 2019.

  152. Silva HD, Cerqueira MA, Vicente AA (2015) Influence of surfactant and processing conditions in the stability of oil-in-water nanoemulsions. J Food Eng 167:89–98

    CAS  Google Scholar 

  153. Silva HD, Beldíková E, Poejo J, Abrunhosa L, Serra AT, Duarte CMM, Brányik T, Cerqueira MA, Pinheiro AC, Vicente AA (2019) Evaluating the effect of chitosan layer on bioaccessibility and cellular uptake of curcumin nanoemulsions. J Food Eng 243:89–100

    CAS  Google Scholar 

  154. Singha S, Bhattacharya B, Basu S (2016) 20-Process technology of nanoemulsions in food processing. In: Grumezescu AM (ed) Encapsulations. Elsevier Inc.

  155. Smith RI, Cohen SM, Doull J, Feron VJ, Goodman JI, Marnett LJ, Portoghese PS, Waddell WJ, Wagner BM, Adams TB (2003) GRAS Flavoring substances 21. Food Technol 57(5)

  156. Solans C, Sole I (2012) Nano-emulsions: formation by low-energy methods. Curr Opinion Colloid Interf Sci 17(5):246–254

    CAS  Google Scholar 

  157. Solans C, Izquierdo P, Azemar N, Garcia-Celma MJ (2005) Nano-emulsions. Curr Opin Colloid Interf Sci 10(3-4):102–110

    CAS  Google Scholar 

  158. Soldatov DV, Ripmeester JA (2004) Supramolecular chemistry. In: Atwood JL, Steed JW (eds) Encyclopedia of Supramolecular chemistry. CRC Press

  159. Sole I, Maestro A, Gonzalez C, Solans C, Gutierrez JM (2006a) Optimization of nano-emulsion preparation by low-energy methods in an ionic surfactant system. Langmuir 22:8326–8332

    CAS  PubMed  Google Scholar 

  160. Sole I, Maestro A, Pey CM, Gonzalez C, Solans C, Gutierrez JM (2006b) Nano-emulsions preparation by low energy methods in an ionic surfactant system. Colloid Surface A 288:138–143

    CAS  Google Scholar 

  161. Sole I, Pey CM, Maestro A, Gonzalez C, Porras M, Solans C, Gutierrez JM (2010) Nano-emulsions prepared by the phase inversion composition method: preparation variables and scale up. J Colloid Interface Sci 344(2):417–423

    CAS  PubMed  Google Scholar 

  162. SONOMECHANICS. Barbell Horn Ultrasonic Technology. https://sonomechanics.com/barbell-horn-ultrasonic-technology/. Accessed 25 May 2019.

  163. Sotomayor-Gerding D, Oomah BD, Acevedo F, Morales E, Bustamante M, Shene C, Rubilar M (2016) High carotenoid bioaccessibility through linseed oil nanoemulsions with enhanced physical and oxidative stability. Food Chem 199:463–470

    CAS  PubMed  Google Scholar 

  164. STANSTED (2019) High pressure components-valves: Stansted fluid power. http://www.highpressurecomponents.co.uk/high_pressure_valves.html Accessed 17 May 2019.

  165. Su D, Zhong Q (2016) Lemon oil nanoemulsions fabricated with sodium caseinate and Tween20 using phase inversion temperature method. J Food Eng 171:214–221

    CAS  Google Scholar 

  166. Sung B, Prasad S, Gupta SC, Patchva S, Aggrawal BB (2012) Regulation of inflammation-mediated chronic diseases by botanicals. In: Shyur L-F, Lau ASY (eds) Advances in botanical research, vol 62. Elsevier Inc., pp 57–132

  167. Surburg H, Panten J (2006) Common fragrance and flavor materials Weinheim. Wiley-VCH Verlag GmbH & Co., Germany

    Google Scholar 

  168. Tadros TF (2005) Applied surfactants, principles and applications. WILEY-VCH Verlag GmbH & Co., Weinheim

    Google Scholar 

  169. Tan KW, Tang SY, Thomas R, Vasanthakumari N, Manickam S (2016) Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation. Pure Appl. Chem. 88(1-2):43–60

    CAS  Google Scholar 

  170. Tang SY, Shridharan P, Sivakumar M (2013) Impact of process parameters in the generation of novel aspirin nanoemulsions- comparative studies between ultrasound cavitation and microfluidizer. Ultrason Sonochem 20(1):485–497

    CAS  PubMed  Google Scholar 

  171. Tang H, Xiang S, Li X, Zhou J, Kuang C (2019) Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion. PlusOne 14(4)

  172. Taylor GI (1932) The viscosity of a fluid containing small drops of another fluid. Proc R Soc A 138(834):41–48

    CAS  Google Scholar 

  173. Taylor GI (1934) The formation of emulsions in definable fields of flow. Proc R Soc A 146(858)

    CAS  Google Scholar 

  174. Thankur RK, Villette C, Aubry JM, Delaplace G (2008) Dynamic emulsification and catastrophic phase inversion of lecithin-based emulsions. Colloid Surface A 315(1–3):285–293

    Google Scholar 

  175. Tolosa L-I, Forgiarini A, Moreno P, Salager J-L (2006) Combined effects of formulation and stirring on emulsion drop size in the vicinity of three-phase behavior of surfactant-oil water systems. Ind Eng Chem Res 45(11):3810–3814

    CAS  Google Scholar 

  176. Tubtimsri S, Limmatvapirat C, Limsirichaikul S, Akkaramongkolporn P, Inoue Y, Limmatvapirat S (2018) Fabrication and characterization of spearmint oil loaded nanoemulsions as cytotoxic agents against oral cancer cell. Asian J Pharm Sci 13(5):425–437

    Google Scholar 

  177. Tucker IM, Petkov JT, Jones C, Penfold J, Thomas RK, Rogers SE, Terry AE, Heenan RK, Grillo I (2012) Adsorption of polymer-surfactant mixtures at the oil-water interface. Langmuir 28(42):14974–14982

    CAS  PubMed  Google Scholar 

  178. Van der Zwan E, Schroen K, van Dijke K, Boom R (2006) Visualization of droplet break-up in pre-mix membrane emulsification using microfluidic devices. Colloid Surface A 277(1-3):223–229

    Google Scholar 

  179. Walia N, Dasgupta N, Ranjan S, Chen L, Ramalingam C (2017) Fish oil based vitamin D nanoencapsulation by ultrasonication and bioaccessibility analysis in simulated gastro-intestinal tract. Ultrason Sonochem 39:623–635

    CAS  PubMed  Google Scholar 

  180. Walstra, P (1991) Principles of emulsion formation. In H. N. Stein (Ed.), The preparation of dispersions, IACIS Conference/Event 439 of the EFChE. Veldhoven, The Netherlands, October 14–16: IACIS

  181. Wang, C, Killpatric, A, Humphrey, A & Guo, M (2019) Whey protein functional properties and applications in food formulations. In M. Guo (Ed.), Whey protein production, chemistry, functionality, and applications: Wiley

  182. Ward AFH, Tordai L (1946) Time-dependence of boundary tensions of solutions I. The role of diffusion in time-effects. J Chem Phys 14:453–461

    CAS  Google Scholar 

  183. Wei TK, Manickam S (2012) Response surface methodology, an effective strategy in the optimization of the generation of curcumin-loaded micelles. Asia-Pac J Chem Eng 7(S1):S125–S133

    CAS  Google Scholar 

  184. Wijaya W, Harfieyanto RC, Dewettinck K, Patel A, Van der Meeren P (2019) Whey protein isolate-low methoxyl pectin nanocomplexes improve physicochemical and stability properties of quercetin in a model fat-free beverage. Food Funct 10:986–996

    CAS  PubMed  Google Scholar 

  185. Wooster TJ, Golding M, Sanguansri P (2008) Impact of oil type on nanoemulsion formation and Ostwald ripening stability. Langmuir 24(22):12758–12765

    CAS  PubMed  Google Scholar 

  186. Wu Y, Iglauer S, Shuler P, Tang Y, Goddard WA (2010) Alkyl polyglycoside-Sorbitan ester formulations for improved oil recovery. Tenside Surf Det 47(5):280–287

    CAS  Google Scholar 

  187. Wypych G (2001) Solvents use in various industries. In: Wypych G (ed) Handbook of solvents. William Andrew Publishing, Toronto

    Google Scholar 

  188. Yang Y, McClements DJ (2013) Encapsulation of vitamin E in edible emulsions fabricated using a natural surfactant. Food Hydrocolloid 30(2):712–720

    Google Scholar 

  189. Yerramilli M, Ghosh S (2017) Long-term stability of sodium caseinate-stabilized nanoemulsions. J Food Sci Technol 54(1):82–92

    CAS  PubMed  PubMed Central  Google Scholar 

  190. Yerramilli M, Longmore N, Ghosh S (2017) Improved stability of nanoemulsions by partial replacement of sodium caseinate with pea protein isolate. Food Hydrocolloid 64:99–111

    CAS  Google Scholar 

  191. Yi J, Li Y, Zhong F, Yokoyama W (2014) The physicochemical stability and in vitro bioaccessibility of beta-carotene in oil-in-water sodium caseinate emulsions. Food Hydrocolloid 35:19–27

    CAS  Google Scholar 

  192. Yildirim ST (2015) Formulation, characterization and antimicrobial effect of cinnamon oil nanoemulsions. Middle East Technical University

  193. Yildrim ST, Oztop MH, Soyer Y (2017) Cinnamon oil nanoemulsions by spontaneous emulsification: formulation, characterization and antimicrobial activity. LWT- Food Sci Technol 84:122–128

    Google Scholar 

  194. Yunfei H, Yazhuo S, Honglai L, Dominique L, Anniina S (2012) Surfactant adsorption onto interfaces: measuring the surface excess in time. Langmuir 28(6):3146–3151

    CAS  PubMed  Google Scholar 

  195. Zeng L, Xin X, Zhang Y (2017) Development and characterization of promising cremophor El-stabilized O/W nanoemulsions containing short-chain alcohols as a cosurfactant. RSC Adv 7:19815–19827

    CAS  Google Scholar 

  196. Zhou WY, Wang M, Cheung WL (2011) Selective laser sintered poly (L-lactide)/carbonated hydroxyapatite nanocomposite scaffolds: a bottom-up approach. In: Reddy BSR (ed) Advances in diverse industrial applications of nanocomposites. InTech, Croatia

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Conflict of Interest

The author declares that there is no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Saffarionpour, S. Preparation of Food Flavor Nanoemulsions by High- and Low-Energy Emulsification Approaches. Food Eng Rev 11, 259–289 (2019). https://doi.org/10.1007/s12393-019-09201-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12393-019-09201-3

Keywords

Navigation