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Modern Template Design and Biological Evaluation of Cephradine-loaded Magnesium Calcium Silicate Nanocomposites as an Inhibitor for Nosocomial Bacteria in Biomedical Applications

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Abstract

Magnesium calcium silicate nanostructures (MCSNS) loaded with (0.0, 0.6, 0.9, and 1.2 wt%) of Cephradine-drug consisting of mesoporous particles were functionally prepared by sol-gel method and treated at 60oC. Bio-functionally nanostructures were characterized by XRD, SEM, FTIR, diffuse reflectance, UV-Vis absorbance and antimicrobial experiments. MCSNS/Velosef nanostructures showed highly successful loading for Cephradine within the silicate-based matrix. As the concentration of velosef increases in the nanostructure, the optical bandgap decreases. The bactericidal features of prepared xerogel nanodrugs against E.coli and Staphylococcus aureus were investigated. The results reveal that these nanoparticles have a powerful bactericidal ability against the tested bacterial strains. The antibacterial properties of all nanomedicines against E. coli were greater than S.aureus. Overall, the results obtained in this study concluded that MCS loaded with 1.2 wt% Cephradine nanostructures could be a powerful bactericidal agent for the elimination of the emerging nosocomial pathogens. Further, this structure recognizes the conceivable manner for applying in biomedical and pharmaceutical applications.

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Authors and Affiliations

  1. Solid-State Physics Department, Physics Research Division, National Research Centre, 33 El- Bohouth St, Dokki, Giza, 12622, Egypt

    Amany M. El Nahrawy, Ali B. Abou Hammad & A. M. Mansour

  2. Water Pollution Research Department, Environmental Research Division, National Research Centre, 33 El-Bohouth St, Dokki, Giza, 12622, Egypt

    Bahaa A. Hemdan

  3. Microbial Chemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, 33 El Bohouth St, Dokki, Giza, 12622, Egypt

    Abdelmageed M. Othman

  4. Physics Department-Science College, Jazan University, Jizan, Saudi Arabia

    Amal M. Abouelnaga

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  1. Amany M. El Nahrawy
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El Nahrawy, A.M., Hemdan, B.A., Abou Hammad, A.B. et al. Modern Template Design and Biological Evaluation of Cephradine-loaded Magnesium Calcium Silicate Nanocomposites as an Inhibitor for Nosocomial Bacteria in Biomedical Applications. Silicon 13, 2979–2991 (2021). https://doi.org/10.1007/s12633-020-00642-8

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