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Synthesis and characterization of thermoresponsive polymeric nanoparticles

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Abstract

We synthesized drug-loaded thermoresponsive poly(N-isopropylacrylamide) with acrylic acid (poly(NIPAM-co-AA)) nanoparticles. Dynamic light scattering analysis showed that the size of poly (NIPAM-co-AA) nanoparticles was significantly affected by temperatures, indicating that the sizes were changed from 400 nm at 25°C to 100 nm at 37°C. 1H nuclear magnetic resonance (NMR) and fourier transform infrared spectroscopy (FT-IR) analysis demonstrated the synthesis of poly(NIPAM-co-AA) nanoparticles, showing that drugs (e.g., doxorubicin, retinoic acid) were conjugated with poly(NIPAM-co-AA) nanoparticles. We also analyzed the cumulative release of drugs in a temporal manner, indicating that doxorubicin was highly released from poly(NIPAM-co-AA) nanoparticles at 48 hours compared to retinoic acid. Therefore, this thermoresponsive drug-loaded poly (NIPAM-co-AA) nanoparticle could be a powerful tool for drug delivery and release applications.

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Authors and Affiliations

  1. Department of Bionano Engineering, Hanyang University, Ansan, Korea

    Boram Ku

  2. Department of Mechanical Engineering, Sogang University, Seoul, Korea

    Hye In Seo & Bong Geun Chung

Authors
  1. Boram Ku
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  2. Hye In Seo
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  3. Bong Geun Chung
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Correspondence to Bong Geun Chung.

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Ku, B., Seo, H.I. & Chung, B.G. Synthesis and characterization of thermoresponsive polymeric nanoparticles. BioChip J 8, 8–14 (2014). https://doi.org/10.1007/s13206-014-8102-6

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  • DOI: https://doi.org/10.1007/s13206-014-8102-6

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