Skip to main content
SpringerLink
Log in

Tensile properties, cell adhesion, and drug release behavior of chitosan-silver-gelatin nanohybrid films and scaffolds

  • Articles
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

Drug-loaded nanohybrid films and porous scaffolds were prepared using chitosan, Ag nanoparticles and gelatin using a solution casting and freeze-drying method, respectively. Gelatin was used to incorporate the cell onto the surface of the scaffolds and the nanohybrid films. 1-[2-hydroxyethyl]-2-methyl-5-nitroimidazole) (Metronidazole (MTZ) was used as a model drug. The small percentage of Ag nanoparticles in the nanohybrid films and scaffolds produced significantly higher cell proliferation and levels of drug release. The tensile properties showed improvement in strength by Ag nanoparticles reinforcement at the expense of elongation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. B. Thapa, J. A. Whitlock, K. G. Brockman Worrell, P. Gideon, E. F. Mitchel, Jr., P. Roberson, R. Pais, and W. A. Ray, Cancer, 83, 1461 (1998).

    Article  CAS  Google Scholar 

  2. World Health Organization, WHO Drug Information, 13, 249 (1999).

    Google Scholar 

  3. J. C. Carey and M. A. Klebanoff, Am. J. Obstet. Gynecol., 192, 1341 (2005).

    Article  Google Scholar 

  4. M. N. Kumar, R. A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A. Domb, Chem. Rev., 104, 6017 (2004).

    Article  Google Scholar 

  5. Y. I. Jeong, D. H. Seo, D. G. Kim, C. Choi, M. K. Jang, J. W. Nah, and Y. Park, Macromol. Res., 17, 538 (2009).

    CAS  Google Scholar 

  6. J. P. Diorio, L. Stojanovic, A. Yardimci, D. L. Amrani, S. Helgerson, and F. Vega, Proc. Microscopy and Microanalysis, Honolulu, Hawaii, USA, July 31–August 4, 2005.

  7. A. Ito, A. Mase, Y. Takizawa, M. Shinkai, H. Honda, K. Hata, M. Ueda, and T. Kobayashi, J. Biosci. Bioeng., 95, 196 (2003).

    CAS  Google Scholar 

  8. S. I. Jeong, Y. M. Lee, and H. Shin, Macromol. Res., 16, 567 (2008).

    CAS  Google Scholar 

  9. A. Mizuno, M. Mitsuiki, and M. Motoki, J. Agric. Food Chem., 48, 3286 (2000).

    Article  CAS  Google Scholar 

  10. K. D. Min, W. H. Park, J. H. Youk, and Y. J. Kwak, Macromol. Res., 16, 626 (2008).

    CAS  Google Scholar 

  11. N. Grier, Silver and Its Compound, 3rd edition, S. S. Block, Ed., Lea & Febiger, Philadelphia, 1983, vol. 375.

    Google Scholar 

  12. N. A. Peppas and S. R. Lustig, Ann. N.Y. Acad. Sci., 446, 26 (1985).

    Article  CAS  Google Scholar 

  13. J. H. Do, J. H. An, Y. S. Joun, D. J. Chung, and J. H. Kim, Macromol. Res., 16, 695 (2008).

    CAS  Google Scholar 

  14. Y. Zhou, D. Yang, X. Chen, Q. Xu, F. Lu, and J. Nie, Biomacromolecules, 9, 349 (2008).

    Article  CAS  Google Scholar 

  15. A. Pattani, V. B. Patravale, L. Panicker, and P. D. Potdar, Mol. Pharm., 6, 345 (2009).

    Article  CAS  Google Scholar 

  16. R. Guo, L. Zhang, H. Qian, R. Li, X. Jiang, and B. Liu, Langmuir, 26, 5428 (2010).

    Article  CAS  Google Scholar 

  17. E. P. Giannelis, Adv. Mater., 8, 29 (1996).

    Article  CAS  Google Scholar 

  18. S. A. Agnihotrym, N. N. Mallikarjuna, and T. M. Aminabhavi, J. Control. Release, 100, 5 (2004).

    Article  Google Scholar 

  19. B.-S. Liu and T.-B. Huang, Macromol. Bio., 8, 932 (2008).

    Article  CAS  Google Scholar 

  20. R. L. Hong and J. Y. Yu, J. Biomed. Mater., 71, 52 (2004).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Polymer Science and Engineering, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411 008, India

    V. K. Rana, Omkar S. Kushwaha & RajPal Singh

  2. Department of Chemical Technology, North Maharashtra University, Jalgaon, 425001, India

    Satyendra Mishra

  3. Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, Korea

    Chang-Sik Ha

Authors
  1. V. K. Rana
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Omkar S. Kushwaha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. RajPal Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Satyendra Mishra
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chang-Sik Ha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to RajPal Singh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rana, V.K., Kushwaha, O.S., Singh, R. et al. Tensile properties, cell adhesion, and drug release behavior of chitosan-silver-gelatin nanohybrid films and scaffolds. Macromol. Res. 18, 845–852 (2010). https://doi.org/10.1007/s13233-010-0905-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-010-0905-2

Keywords

Search

Navigation