Abstract
This paper reviews applications of experimental modelling in vascular access for hemodialysis. Different techniques that are used in in-vitro experiments are bulk pressure and flow rate measurements, Laser Doppler Velocimetry and Vector Doppler Ultrasound point velocity measurements, and whole-field measurements such as Particle Image Velocimetry, Ultrasound Imaging Velocimetry, Colour Doppler Ultrasound, and Planar Laser Induced Fluorescence. Of these methods, the ultrasound techniques can also be used in-vivo, to provide realistic boundary conditions to in-vitro experiments or numerical simulations. In the reviewed work, experimental modelling is mainly used to support computational models, but also in some cases as a tool on its own. It is concluded that, to further advance the utility of computational modelling in vascular access research, a rigorous verification and validation procedure should be adopted. Experimental modelling can play an important role in both in-vitro validation, and the quantification of the accuracy, uncertainty, and reproducibility of in-vivo measurement methods.
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S. Drost, N. Alam, J. G. Houston and D. Newport declares that they have no conflict of interest.
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This article does not contain any studies with human participants or animals performed by any of the authors.
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This project has received funding from the European Unions Seventh Framework Programme for research, technological development and demonstration under Grant Agreement No. 324487.
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Associate Editors James E Moore Jr. and Michael Walsh oversaw the review of this article.
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Drost, S., Alam, N., Houston, J.G. et al. Review of Experimental Modelling in Vascular Access for Hemodialysis. Cardiovasc Eng Tech 8, 330–341 (2017). https://doi.org/10.1007/s13239-017-0311-4
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DOI: https://doi.org/10.1007/s13239-017-0311-4