Skip to main content
SpringerLink
Log in

Novel method to graft chitosan on the surface of hydroxyapatite nanoparticles via “click” reaction

  • Published:
Chemical Research in Chinese Universities Aims and scope

Abstract

In order to tune the surface properties of hydroxyapatite(HA) nanoparticles and prevent them from aggregation, an efficient method was proposed to graft chitosan(CS) molecules on the surface of HA via “click” reaction. Thermal gravimetric analysis(TGA) shows that CS was successfully grafted on the surface of HA nanoparticles and the grafting amount was about 8.9 g of CS on per hundred grams of HA. The grafted chitosan chains can prevent HA nanoparticles from aggregation and greatly enhance the colloidal stability of HA in water. The 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay demonstrats that the cytotoxicity of CS modified HA(HA-CS) is negligible and thus HA-CS may find potential application in biomedical fields.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. McConnell D., Frajola W. J., Deamer D. W., Science, 1961, 133, 281

    Article  CAS  Google Scholar 

  2. Yu C. C., Chang J. J., Lee Y. H., Lin Y. C., Wu M. H., Yang M. C., Chien C. T., Mater. Lett., 2013, 93, 133

    Article  CAS  Google Scholar 

  3. Qian J. M., Xu M. H., Suo A. L., Yu T. F., Yong X. Q., Mater. Lett., 2013, 93, 72

    Article  CAS  Google Scholar 

  4. Zhang J. Z., Li D. D., Liu G. F., Wu Q., Wang J. C., Chem. J. Chinese Universities, 2012, 33(2), 219

    Article  Google Scholar 

  5. Supova M., J. Mater. Sci., Mater. M., 2009, 20, 1201

    Article  CAS  Google Scholar 

  6. Wei J. C., He P., Liu A. X., Chen X. S., Wang X. H., Jing X. B., Macromol. Biosci., 2009, 9, 1237

    Article  CAS  Google Scholar 

  7. Wei J. C., Liu A. X., Chen L., Zhang P. B., Jing X. B., Macromol. Biosci., 2009, 9, 631

    Article  CAS  Google Scholar 

  8. Lee H. J., Choi H. W., Kim K. J., Lee S. C., Chem. Mater., 2006, 18, 5111

    Article  CAS  Google Scholar 

  9. Hong Z. K., Zhang P. B., He C. L., Qiu X. Y., Liu A. X., Chen X. X., Jing X. B., Biomaterials, 2005, 26, 6296

    Article  CAS  Google Scholar 

  10. Chen J., Chen W., Deng C., Meng F. H., Zhong Z. Y., J. Polym. Sci., Poly. Chem., 2011, 49, 4379

    Article  CAS  Google Scholar 

  11. Wang Y., Dai J., Zhang Q. C., Xiao Y., Lang M. D., Appl. Surf. Sci., 2010, 256, 6107

    Article  CAS  Google Scholar 

  12. Wang Y., Zhang X., Yan J. L., Xiao Y., Lang M. D., Appl. Surf. Sci., 2011, 257, 6233

    Article  CAS  Google Scholar 

  13. Sun Y. H., Deng Y., Ye Z. Y., Liang S. S., Tang Z. H., Wei S. C., Colloid. Surface B, 2013, 111, 107

    Article  CAS  Google Scholar 

  14. Liu Y. D., Cui H. T., Zhuang X. L., Zhang P. B., Cui Y., Wang X. H., Wei Y., Chen X. S., Macromol. Biosci., 2013, 13, 356

    Article  CAS  Google Scholar 

  15. Yu T., Liu Y., Wang Y., Jing X. B., Zhang P. B., Chen X. S., Chem. J. Chinese Universities, 2009, 30(7), 1439

    CAS  Google Scholar 

  16. Tang Y. F., Liu J. G., Wang Z. L., Wang Y., Cui L. G., Zhang P. B., Chen X. S., Chin. J. Polym. Sci., 2014, 32, 805

    Article  CAS  Google Scholar 

  17. Zhang P. B., Wu H. T., Wu H., Lu Z. W., Deng C., Hong Z. K., Jing X. B., Chen X. S., Biomacromolecues, 2011, 12, 2667

    Article  CAS  Google Scholar 

  18. Ding C. C., Teng S. H., Pan H., Mater. Lett., 2012, 79, 72

    Article  CAS  Google Scholar 

  19. Pu X. M., Wei K., Zhang Q. Q., Mater. Lett., 2013, 94, 169

    Article  CAS  Google Scholar 

  20. Schlossbauer A., Schaffert D., Kecht J., Wagner E., Bein T., J. Am. Chem. Soc., 2008, 130, 12558

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Nanchang University, Nanchang, 330031, P. R. China

    Junchao Wei, Peiyao Guo-Wang, Haobin Zhang, Yanfeng Dai & Tianxi Liu

  2. State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China

    Junchao Wei & Tianxi Liu

  3. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China

    Liguo Cui

Authors
  1. Junchao Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peiyao Guo-Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Liguo Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Haobin Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yanfeng Dai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tianxi Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Junchao Wei or Tianxi Liu.

Additional information

Supported by the National Natural Science Foundation of China(Nos.51203073, 51463013), the Natural Science Foundation of Jiangxi Province of China(No.20142BAB203018) and the Natural Science Foundation of Education Department of Jiangxi Province of China(No.GJJ13107).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wei, J., Guo-Wang, P., Cui, L. et al. Novel method to graft chitosan on the surface of hydroxyapatite nanoparticles via “click” reaction. Chem. Res. Chin. Univ. 30, 1063–1065 (2014). https://doi.org/10.1007/s40242-014-4166-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40242-014-4166-z

Keywords

Search

Navigation