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DNA Nanotechnology for Multimodal Synergistic Theranostics

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A Correction to this article was published on 03 July 2021

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Abstract

Over the past decade, DNA nanotechnology has developed rapidly due to its unique characteristics, such as excellent biocompatibility, high programmability, good predictability, automatically chemical synthesis, and so on. So far, a variety of DNA-based nanostructures, from small to large and simple to complex, have been designed and synthesized with controllable size and shape in one, two, or three dimensions. Therefore, DNA has become a kind of competitive materials for biosensing, bioimaging and biomedicine. In particular, the integration of DNA nanotechnology with multimodal synergistic theranostics can not only achieve accurate cancer diagnosis by the sensitive and accurate detection of cancer biomarkers, but also achieve enhanced anti-cancer therapeutic efficacy, which promote the development of DNA nanotechnology and nanomedicine. In this review, we first give a comprehensive introduction of DNA nanotechnology, and then summarize the DNA self-assembly and amplification strategies for the construction of functional nanoplatforms for multimodal synergistic theranostics. Finally, the challenges and opportunities faced by DNA nanotechnology in biomedicine are discussed.

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Acknowledgements

The authors gratefully appreciate the support from the National Natural Science Foundation of China (22076087), the Special Funds of Taishan Scholar Program of Shandong Province (tsqn20161028), the National Science Outstanding Youth Fund of Shandong Province (ZR2020JQ08), the Youth Innovation Technology Program of Shandong Province (2019KJC029), the Collaborative Innovation Program of Jinan (2018GXRC033), and the Open Project of Chemistry Department of Qingdao University of Science and Technology (QUSTHX201928).

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  1. College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, China

    Kai-Xin Yu, Zhen-Jie Qiao & Sai Bi

  2. Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China

    Wei-Ling Song

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  1. Kai-Xin Yu
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Yu, KX., Qiao, ZJ., Song, WL. et al. DNA Nanotechnology for Multimodal Synergistic Theranostics. J. Anal. Test. 5, 112–129 (2021). https://doi.org/10.1007/s41664-021-00182-z

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