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Drug release behaviour and mechanism from unmodified and in situ modified bacterial cellulose

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Abstract

Bacterial cellulose (BC) is a suitable drug delivery carrier owing to the nanofibrous micro and mesoporous structure. One of the unique aspects is the tunability of BC microstructure by the addition of certain additives in the growth medium during the synthesis of cellulose by bacteria. In the present work, BC was in situ modified by adding Polyethylene glycol 2000 (PEG 2000). Effect of in situ modification on crystallinity, chemical composition, microstructure and morphology and, porosity was studied by XRD, FTIR, SEM and BET, followed by the effect on drug (Diclofenac sodium) loading and release kinetics. As a non-incorporating in situ modifier, PEG2000 increased the overall porosity, pore volume and decreased the specific surface area with no significant effect on crystallinity. In vitro, drug release studies revealed that a huge burst release for PEG modified BC as compared to pristine BC. The mechanism of release is further investigated by mathematical modelling. This work opens up avenues of exploring the wide possibility of tuning immediate and sustained drug release from bacterial cellulose for various release applications.

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Acknowledgements

Authors acknowledge the financial support of DST-FAST TRACK grant SB/FTP/ETA-0073/2014. Authors also thank Indian Institute of Technology, Hyderabad for providing necessary research infrastructure to carry out this work, with special thanks to Ms Alekhya Kunamalla, doctoral student, Chemical Engineering, IIT Hyderabad for her help in BET analysis.

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Authors and Affiliations

  1. Department of Materials Science and Metallurgical Engineering, Indian Institute of Technology, Hyderabad, NH9, Kandi Village, Sangareddy, Telangana, 502285, India

    Shivakalyani Adepu & Mudrika Khandelwal

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  1. Shivakalyani Adepu
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  2. Mudrika Khandelwal
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The manuscript was written through the contributions of all authors. All authors have given approval to the final version of the manuscript.

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Correspondence to Mudrika Khandelwal.

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This article is part of the Special Issue: Indian National Young Academy of Science (INYAS).

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Adepu, S., Khandelwal, M. Drug release behaviour and mechanism from unmodified and in situ modified bacterial cellulose. Proc.Indian Natl. Sci. Acad. 87, 110–120 (2021). https://doi.org/10.1007/s43538-021-00012-x

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