Polyglycolic acid synthetic absorbable sutures

doi:10.1016/0002-9610(71)90139-5

The American Journal of Surgery

Volume 121, Issue 5, May 1971, Pages 561-565

https://doi.org/10.1016/0002-9610(71)90139-5 Get rights and content

Abstract

A laboratory study of the characteristics of a synthetic absorbable polyglycolic acid polymer suture (Dexon) is presented. The polyglycolic acid sutures were found to be well tolerated by the abdominal wall tissues in rabbits in both clean and infected wounds. Tissue reactivity and tensile strength of the experimental sutures compare favorably with silk, cotton, Dacron, and plain and chromic catgut sutures. The polyglycolic acid sutures handle with the ease of silk while being absorbed more completely than catgut.

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Cited by (37)

Microparticulate polymers and hydrogels for wound healing
2016, Wound Healing Biomaterials
Traditional treatment of open wounds engaged bandages such as gauze of cotton, wool or lint with the primary function to keep the wound dry. Findings now show that proper natural or synthetic biomaterials achieve rapid wound healing by preventing desiccation. Hydrogels, ie, a network of hydrophilic polymer chains with water dispersed inside the network, provide an excellent system for wound healing. Polymers, be they from natural origins (eg, polysaccharides and proteoglycans) or synthetic (eg, polyglycolic acid, polylactic acid, polyacrylic acid, poly-ε-caprolactone, polyvinyl pyrrolidone, polyvinyl alcohol and polyethylene glycol) exhibit wound healing properties. Micro- and nanoparticulate delivery systems designed with these polymers have also been applied for wound healing. Furthermore, delivering polystyrene particles to the wound surface to induce an inflammatory response is a new concept. This chapter offers an overview of polymer and hydrogels as well as the various novel delivery systems for wound healing with advancements in patents, clinical trials and marketed products.
Management of Soft Tissue Injuries
2012, Oral and Maxillofacial Trauma
Emergency department repair of hand lacerations using absorbable vicryl sutures
1997, Journal of Emergency Medicine
The use of absorbable suture material has a number of potential advantages when compared to nonabsorbable suture. We conducted a 5-year retrospective study of 102 patients with hand lacerations and compared the quality of scar formation and healing in these patients. Those patients who did not have tendon, nerve, or bone injury were included in the study. Lacerations were repaired with either 5-0 Vicryl or nylon. There were no reported complications or infections in any study group patient. The quality of scar, when compared visually and by palpation, was the same at the end of 6 months. In addition, there was no difference in the incidence of scar retraction. We conclude that the use of absorbable suture material is an acceptable alternative in the repair of hand lacerations.
Subcuticular Sutures and the Rate of Inflammation in Noncontaminated Wounds
1995, Annals of Emergency Medicine
Study objective: To determine whether buried, absorbable, subcuticular sutures increase the degree of inflammation in noncontaminated wounds.
Design: Randomized, blinded, prospective trial. Setting: Laboratory. Participants: Eleven Sprague-Dawley rats weighing 300 to 325 g. Interventions: Four wounds were made on each rat. Two wounds on each were closed with three interrupted buried, absorbable, subcuticular sutures 6-0 polyglactin 910 and running 5-0 nylon skin sutures. The other two wounds were closed with running 5-0 nylon skin sutures alone. Results: Fourteen days after the sutures were placed, the animals were killed, and histologic preparations were made from each wound. Each sample was scored on a scale of 0 to 3 for the presence of inflammatory infiltrates, fibroplasia and capillary proliferation, necrosis, exudates, giant cells, and edema. We determined a total wound score by adding the scores from each category. The mean total wound score was 4.46±2.92 for those closed with buried, absorbable, subcuticular sutures and 4.91±2.56 for those closed without buried, absorbable, subcuticular sutures. Using the Wilcoxon rank-sum test, we found no statistically significant difference in mean total wound score of wounds closed with and without buried, absorbable, subcuticular sutures (α=.01). The probability of detecting a twofold difference in total wound scores was 60% (β=.40). Conclusion: Buried, absorbable, subcuticular sutures do not significantly increase the degree of inflammation in noncontaminated wounds. [Austin PE, Dunn KA, Eily-Cofield K, Brown CK, Wooden WA, Bradfield JF: Subcuticular sutures and the rate of inflammation in noncontaminated wounds. Ann Emerg Med March 1995;25:328-330.]
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Foreign bodies embedded in soft tissue can cause toxic and allergic reactions, inflammation, or infection, but the severity of these complications varies widely. Removal can be difficult and time consuming, and the potential damage to tissues caused by the procedure must be weighed against the risk posed by a particular foreign body. Plain and mammographic radiography, xeroradiography, computed tomography, and ultrasonography can be used to detect foreign bodies suspected during clinical evaluation. The exact position of an object buried in soft tissue is difficult to determine using two-dimensional imaging techniques. Surface markers, multiple-projection radiographs, wire grids, fluoroscopy, or stereotaxic devices may help to locate it. Not all foreign bodies are discovered during the initial patient encounter; several signs reveal the presence of a retained foreign body in a wound.
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1988, Journal of the American Academy of Dermatology

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^☆: This work was supported in part by Grant #106 from the Davis and Geck Company, Pearl River, New York.

¹: From the Department of Surgery, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611.

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Scientific paperPolyglycolic acid synthetic absorbable sutures☆

Abstract

Am J Surg

Wound healing: experimental and statistical study. II. Sutures and ligatures

Surg Gynec Obstet

Tissue reaction to surgical sutures: repair and regeneration

Scientific paper
Polyglycolic acid synthetic absorbable sutures☆