The effect of cadmium administration on the biliary excretion of copper and zinc and tissue disposition of these metals

doi:10.1016/0013-9351(81)90187-0

Environmental Research

Volume 26, Issue 1, October 1981, Pages 95-104

https://doi.org/10.1016/0013-9351(81)90187-0 Get rights and content

Abstract

Administration of a single subcutaneous dose of cadmium (1.5 mg/kg) to male rats resulted in significant decreases in copper concentration of the bile at 4 to 24 hr after treatment. Thereafter the copper concentration returned to control limits for the duration of the experiment (14 days). Biliary zinc concentrations were markedly increased from 3 to 7 days after treatment. Changes in plasma concentrations of zinc and copper were essentially the reverse of those seen in bile. Cysteine and glutathione, given 3 hr after cadmium, exacerbated the effect on biliary copper excretion, while pretreatment with actinomycin D eliminated the effect of cadmium. In contrast, the combined cadmium and actinomycin D treatment produced a massive increase in zinc concentration in the bile after 3–4 hr and a significant increase in biliary cadmium as early as 0.5 hr after dosing. Long-term administration of cadmium in the diet (100 ppm) progressively reduced biliary copper concentrations, but had no effect on biliary zinc concentrations.

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The effect of cadmium administration on the biliary excretion of copper and zinc and tissue disposition of these metals

Abstract

Environ. Res.

Chem. Biol. Inter.

Biochem. Pharmacol.

Life Sci.

Biochem. Biophys. Res. Commun.

Environ. Res.

Arch. Biochem. Biophys

Anal. Biochem.

Bioinorg. Chem.

Chem. Biol. Inter.

Arch. Biochem. Biophys.

Heavy metal toxicities

Quart. Rev. Biophys

Effects of dietary cadmium and zinc on rats maintained on diets low in copper