Hydrolysis of phosphatidylcholine in aqueous liposome dispersions

doi:10.1016/0378-5173(89)90173-7

International Journal of Pharmaceutics

Volume 50, Issue 1, 15 February 1989, Pages 1-6

https://doi.org/10.1016/0378-5173(89)90173-7 Get rights and content

Abstract

The hydrolysis of phosphatidylcholine was investigated as a function of pH, temperature, buffer concentration and buffer species. The hydrolysis rate of phosphatidylcholine increased with increasing concentration of the buffer species; there was a linear relationship between the buffer concentration and the observed rate constant. The pH profile at zero buffer concentration and at 72°C shows a minimum hydrolysis rate at about pH 6.5. The data were analysed to obtain detailed information on the effect of the buffer species used on the stability. The relationship between the observed rate constant and temperature could be described adequately by the Arrhenius equation.

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Research papersHydrolysis of phosphatidylcholine in aqueous liposome dispersions

Abstract

J. Biol. Chem.

Biochim. Biophys. Acta

Lipid Res.

Chemical Stability and Mitomycin and Anthracycline Antineoplastic Drugs

Solution stability of ciclosidomine

J. Pharm. Sci.

Reaction Mechanisms in Organic Analytical Chemistry

Research papers
Hydrolysis of phosphatidylcholine in aqueous liposome dispersions