Production of 73Se via (p, 3n) and (d, 4n) reactions on arsenic

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Abstract

Excitation functions were measured for 75As(p, xn) 72, 73, 75Se reactions over the energy range of 3–45 MeV and for 75As(d, xn) 72, 73, 75Se reactions from 5 to 56 MeV. Thin targets were prepared by electrolytic deposition of arsenic on Cu-, or Al-backing. The optimum energy ranges for the production of 73Se were found to be Ep = 40 → 30 MeV and Ed = 45 → 33 MeV; theoretical thick target yields of 73Se amount to 38 and 17.6 mCi/μAh, respectively, and the levels of 72, 75Se impurities to <0.2%. An anion-exchange method was developed to separate no-carrier-added radioselenium. Irradiations of As2O3 for 2 h at nominal currents of 2 μA lead to batch yields of 73Se (at EOB) of about 70 mCi in the case of the (p, 3n) reaction and about 35 mCi in the (d, 4n) reaction.

References (25)

  • R. Weinreich et al.

    Production of chromium-48 for application in life sciences

    Int. J. Appl. Radiat. Isot.

    (1980)
  • C.F. Williamson et al.

    Tables of Range and Stopping Power of Chemical Elements for Charged Particles of Energy 0.5 to 500 MeV

    (1966)
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    DAAD Fellow. Present address: Pakistan Institute of Nuclear Science and Technology, Islamabad, Pakistan.

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