Chapter 3 - Drug Release in Biological Tissues

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Abstract

This chapter focuses on the theoretical understanding of the transport of drug in a porous media representation of biological tissues. The derivation of the governing equations using a volume-averaged porous media approach is detailed. This is followed by analytic solution developments that concentrate on the transport of solute in a biological system. The conjugate problem interaction between the fluid and solid phase, known as local mass non-equilibrium, is analyzed in detail and the relative influences of convection and diffusion are investigated. Finally the problem is extended to include the composite nature of biological media. The specific application shown here involves the study of a drug released by a stent within an arterial wall.

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