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Self-amplification of optical activity by chromatography on an achiral adsorbent

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    Such a phenomenon is known as the self-disproportionation of enantiomers. The self-disproportionation of enantiomers has also recently received much attention as a new method for enantiomeric purification.1,2 Recently we discovered the efficient self-disproportionation of enantiomers of enantiomerically enriched N-acyl-1-phenylethylamine derivatives under the conditions of medium pressure liquid chromatography (MPLC).3

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