Lack of regression of atherosclerotic lesions in phytosterol-treated apo E-deficient mice
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Cited by (52)
Plant-derived bioactives
2019, Comprehensive BiotechnologyPostprandial plasma oxyphytosterol concentrations after consumption of plant sterol or stanol enriched mixed meals in healthy subjects
2015, SteroidsCitation Excerpt :The controversy around the potential atherogenicity of plant sterols might relate to the question whether plant sterols are oxidized or not. We and others have previously shown that in transgenic mouse models plant sterol enriched diets lower atherosclerotic lesion development [7–9] while enrichment with oxidized plant sterols (oxyphytosterols) resulted in larger and more severe atherosclerotic lesions [10]. Data regarding origin, metabolism, pathophysiological effects and effects of specific diets on oxyphytosterol metabolism in humans are however scarce.
Dietary phytosterol does not accumulate in the arterial wall and prevents atherosclerosis of LDLr-KO mice
2013, AtherosclerosisCitation Excerpt :One study found that homozygous ABCG5/G8-KO mice without PS supplementation had higher plasma PS concentrations; this increase was not related to the development of atherosclerotic lesion areas [11]. Other studies conducted with apoE-KO mice fed a PS-enriched diet showed that PS plasma concentrations are positively or negatively [12,13] related to the development of atherosclerosis and may inhibit the regression of existing lesions [14]. In agreement with the results of the latter study, an investigation conducted in heterozygous LDLr-KO mice fed PS with or without atorvastatin failed to show an atherogenic effect [15].
Plant Derived Bioactives
2011, Comprehensive Biotechnology, Second EditionPhytosterols and atherosclerosis
2011, Revue de Medecine Interne