Substrate specificity and enantioselectivity of penicillinacylase catalyzed hydrolysis of phenacetyl esters of synthetically useful carbinols
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Perspectives and industrial potential of PGA selectivity and promiscuity
2013, Biotechnology AdvancesCitation Excerpt :Research into enantioselectivity of PGA started in the 60's of the last century and dealt with resolutions of racemic mixtures of α-amino acids and their derivatives (Cole, 1969; Lucente et al., 1965), α-amino alcohols and α-amino nitriles (Romeo et al., 1971). Resolution experiments were later extended to α-substituted α-amino acids (Rossi and Calcagni, 1985), racemic mixtures of β, γ, δ, ε-amino acids (Margolin, 1993; Rossi et al., 1977), aliphatic amines (Rossi et al., 1978), β-aryl-β-amino acids (Soloshonok et al., 1995), β-alkyl-β-amino acids (Soloshonok et al., 1994), phosphonic and phosphonous analogs of alanine (Solodenko et al., 1993), primary or substituted carbinols (Fuganti et al., 1988; Waldmann, 1989), β-amino ketones (Cainelli et al., 1997) and the dipeptide aspartame (Fuganti and Grasselli, 1986). In this review, we will focus on biocatalytic applications exploiting enantioselectivity and promiscuity of prokaryotic PGAs, two properties that were discovered or profoundly studied during the last decade.
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2001, Journal of Molecular Catalysis - B Enzymatic