Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

doi:10.1016/S0040-4039(00)79663-8

Tetrahedron Letters

Volume 32, Issue 10, 4 March 1991, Pages 1343-1346

https://doi.org/10.1016/S0040-4039(00)79663-8 Get rights and content

Abstract

Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

A new method of preparation of optically active nitriles, amides and carboxylic acids is described.

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Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Abstract

Eur. J. Biochem.

J. Chem. Soc. Chem. Commun.

Tetrahedron

Abstract of the annual meating of Japan Society of Bioscience, Biothechnology and Agrochemistry

Tetrahedron Lett.