Synthesis of both enantiomeric forms of 2-substituted 1,3-propanediol monoacetates starting from a common prochiral precursor, using enzymatic transformations in aqueous and in organic media

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Abstract

A direct entry to both enantiomeric forms c and ent-c based on enzyme catalyzed transformations of prochiral compounds of type a and b is described. The catalysts used are carboxyl esterase preparations obtained from crude porcine pancreas lipase.

A direct entry to both enantiomeric forms c and ent-c, based on enzyme catalyzed transformat of prochiral compounds of type a and b is descried. The catalysts used are carboxyl esterase preparations obtained from crude porcine pancreas lipase.

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References (16)

  • J.B. Jones

    Tetrahedron

    (1986)
  • R.A. Wisdom et al.

    Enzyme Microb. Technol.

    (1984)
  • Y.-F. Wong et al.

    Tetrahedron Lett.

    (1985)
  • K. Yokozeki et al.

    Eur. J. Appl. Microbiol. Biotechnol.

    (1982)
  • B. Borgström et al.
    (1984)
There are more references available in the full text version of this article.

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    1H NMR spectra were recorded on a Varian spectrometer (400 MHz) and are referenced relative to tetramethylsilane proton signals at δ 0 ppm. Lipase immobilized on Celite was prepared as described (22). Briefly, 8 g of crude porcine pancreas lipase was dissolved in 80 ml of 18 mm sodium phosphate buffer (pH 8.0).

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