Synthesis of 6S, 7S-anhydro-serricornine.

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Abstract

Diastereoselective and enantioselective reduction of the β-ketoester 3 by yeast to 4 provided the chiral starting material for a synthesis of 4RS,6S,7S-serricornine, having the same configuration as the natural product. This material was converted into optically active and diastereomerically pure 6S,7S-anhydro-serricornine (2).

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