Elsevier

Tetrahedron Letters

Volume 43, Issue 20, 13 May 2002, Pages 3707-3710
Tetrahedron Letters

Facile synthesis of chelating bisphosphine oxides and bisphosphines via palladium-catalyzed bishydrophosphinylation reactions

https://doi.org/10.1016/S0040-4039(02)00609-3Get rights and content

Abstract

A series of functional bisphosphosphine oxides were synthesized in good yields via new Pd-catalyzed bis-hydrophosphinylation reactions of terminal alkynes and diphenylphosphine oxide. The resulting bisphosphine oxides were reduced to their corresponding bisphosphines in quantitative yields via a Ti(OiPr)4-mediated process.

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Acknowledgments

We acknowledge NSF (DMR-9875544) for financial support. W.L. is an Alfred P. Sloan Fellow, an Arnold and Mabel Beckman Young Investigator, a Cottrell Scholar of Research Corp, and a Camille Dreyfus Teacher-Scholar.

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